Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | BPTF | Q12830 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12062694 | 0.89 | LMNA (0.41) | LMNAKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL28211459 | 0.84 | TSHR (0.47) | LMNAKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL13171441 | 0.79 | THRA (0.44) | LMNAMAPTMEN1KMT2ACYP3A4 | |
| SCHEMBL5531032 | 0.76 | POLB (0.37) | LMNAKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL28639005 | 0.75 | TSHR (0.45) | LMNAKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL5531158 | 0.75 | HTR2A (0.46) | LMNAMAPTPOLBTSHRCYP3A4 | |
| SCHEMBL24313567 | 0.74 | L3MBTL1 (0.40) | LMNAKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL19410967 | 0.74 | KDM4E (0.44) | LMNAKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL4599327 | 0.74 | HTT (0.39) | LMNAKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL14293824 | 0.72 | MAPT (0.47) | KDM4EMAPTALDH1A1HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022063106-A1 | INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | BEIGENE, LTD. (KY) | 2022-03-31 | — | — | WO | disclosed |