SCHEMBL24328631

SCHEMBL24328631

CC(=O)OC[C@H]1COc2ccc(C=O)cc2O1

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 2/20 0.45
L3MBTL1 Q9Y468 2/20 0.44
MAPK1 P28482 1/20 0.44
ALDH1A1 P00352 3/20 0.44
HSD17B10 Q99714 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
FFAR1 O14842 6/20 0.41
RECQL P46063 1/20 0.40
TSHR P16473 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.39
MAPT P10636 1/20 0.39
DRD2 P14416 1/20 0.39
DRD4 P21917 1/20 0.39
DRD3 P35462 1/20 0.39
ALOX5 P09917 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26753612 1.00 MTNR1A (0.45) MTNR1AL3MBTL1MAPK1ALDH1A1HSD17B10
SCHEMBL10916152 0.83 MTNR1A (0.48) MTNR1AALDH1A1HSD17B10TDP1TSHR
SCHEMBL15201846 0.83 ALDH1A1 (0.45) MTNR1AALDH1A1HSD17B10TDP1FFAR1
SCHEMBL19776040 0.83 CA2 (0.54) MTNR1AL3MBTL1MAPK1HSD17B10FFAR1
SCHEMBL19776224 0.83 CA2 (0.54) MTNR1AL3MBTL1MAPK1HSD17B10FFAR1
SCHEMBL19776291 0.82 FFAR1 (0.54) MTNR1AL3MBTL1MAPK1FFAR1
SCHEMBL19776654 0.82 DRD2 (0.54) MTNR1AL3MBTL1MAPK1FFAR1DRD2
SCHEMBL19776202 0.82 FFAR1 (0.54) MTNR1AL3MBTL1MAPK1FFAR1
SCHEMBL19776284 0.82 DRD2 (0.54) MTNR1AL3MBTL1MAPK1FFAR1DRD2
SCHEMBL10922317 0.81 ALDH1A1 (0.49) MTNR1AALDH1A1HSD17B10TDP1FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250145634-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2025-05-08 US disclosed
US-20240058340-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER ERASCA, INC. 2024-02-22 US disclosed
US-20230364091-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2023-11-16 US disclosed
US-20230364091-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2023-11-16 US disclosed
US-20230364091-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2023-11-16 US disclosed
CN-115215808-A Compositions and methods for treating cancer 加利福尼亚大学董事会 2022-10-21 CN disclosed
US-11377451-B2 Compositions and methods for treating cancer THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-07-05 US disclosed
US-11377451-B2 Compositions and methods for treating cancer THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-07-05 US disclosed
WO-2022061202-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-03-24 WO disclosed
WO-2022061202-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-03-24 WO disclosed
WO-2022061201-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-03-24 WO disclosed
US-20220064177-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2022-03-03 US disclosed
US-20220064177-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2022-03-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250145634-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER TP53, SLC2A1, EGFR MTNR1A 3420/4885L3MBTL1 3738/4885MAPK1 1392/4885
US-11377451-B2 Compositions and methods for treating cancer TP53, EGFR, SLC2A1 MTNR1A 3907/4885L3MBTL1 3700/4885MAPK1 1416/4885
US-20230364091-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER TP53, EGFR, SLC2A1 MTNR1A 3554/4885L3MBTL1 3803/4885MAPK1 1531/4885
US-20220064177-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER TP53, SLC2A1, EGFR MTNR1A 3420/4885L3MBTL1 3738/4885MAPK1 1392/4885
US-20240058340-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER TP53, EGFR, SLC2A1 MTNR1A 3554/4885L3MBTL1 3803/4885MAPK1 1531/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.