Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.48 |
| ▸ | NOS3 | P29474 | 3/20 | 0.48 |
| ▸ | NOS1 | P29475 | 3/20 | 0.48 |
| ▸ | NOS2 | P35228 | 3/20 | 0.48 |
| ▸ | PLAU | P00749 | 2/20 | 0.48 |
| ▸ | F12 | P00748 | 2/20 | 0.48 |
| ▸ | NCF1 | P14598 | 1/20 | 0.48 |
| ▸ | CLK1 | P49759 | 2/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.39 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | F11 | P03951 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL637579 | 0.79 | NOS3 (0.52) | BACE1NOS3NOS1NOS2PLAU | |
| SCHEMBL27374190 | 0.76 | PLAU (0.48) | BACE1NOS3NOS1NOS2PLAU | |
| SCHEMBL20974756 | 0.76 | CYP2A6 (0.48) | BACE1NOS3NOS1NOS2PLAU | |
| SCHEMBL17152698 | 0.76 | F12 (0.48) | BACE1NOS3NOS1NOS2PLAU | |
| SCHEMBL10030932 | 0.76 | LMNA (0.39) | BACE1NOS3NOS1NOS2PLAU | |
| SCHEMBL31281062 | 0.74 | CDK9 (0.42) | CLK1CDK5CDK5R1MAOADYRK1A | |
| SCHEMBL24317326 | 0.74 | CDK9 (0.42) | CLK1CDK5CDK5R1MAOADYRK1A | |
| SCHEMBL29129392 | 0.73 | CSNK2A1 (0.38) | BACE1NOS3NOS1NOS2PLAU | |
| SCHEMBL29374267 | 0.72 | ALDH1A1 (0.53) | BACE1NOS1 | |
| SCHEMBL1187339 | 0.72 | ALDH1A1 (0.53) | BACE1NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081928-A1 | TRICYCLIC HETEROBIFUNCTIONAL COMPOUNDS FOR DEGRADATION OF TARGETED PROTEINS | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |