Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.30 |
| ▸ | CHRNG | P07510 | 1/20 | 0.30 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.30 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
| ▸ | CHRND | Q07001 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24324476 | 0.82 | SIGMAR1 (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4OPRL1 | |
| SCHEMBL23561133 | 0.71 | CDK4 (0.40) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL20468861 | 0.70 | ALDH1A1 (0.50) | — | |
| SCHEMBL23228760 | 0.69 | TSHR (0.34) | OPRL1 | |
| SCHEMBL12204161 | 0.69 | CHKA (0.43) | CHRNB2CHRNA4 | |
| SCHEMBL9881482 | 0.67 | MAPT (0.44) | CHRNB2CHRNA4 | |
| SCHEMBL8281056 | 0.66 | HTR3A (0.50) | — | |
| SCHEMBL20311310 | 0.64 | CHRNB2 (0.59) | CHRNB2CHRNA4 | |
| SCHEMBL22361873 | 0.64 | CHRNB2 (0.38) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL15706151 | 0.64 | POLB (0.39) | CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076620-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |