Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 4/20 | 0.58 |
| ▸ | KDR | P35968 | 2/20 | 0.58 |
| ▸ | JAK3 | P52333 | 2/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.58 |
| ▸ | DHFR | P00374 | 4/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.47 |
| ▸ | KIT | P10721 | 3/20 | 0.46 |
| ▸ | SRC | P12931 | 3/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5494305 | 0.88 | LCK (0.56) | LCKKDRJAK3MAPK14DHFR | |
| SCHEMBL19943434 | 0.78 | LCK (0.53) | LCKKDRJAK3MAPK14DHFR | |
| SCHEMBL2632884 | 0.78 | LCK (0.57) | LCKKDRJAK3MAPK14ADORA1 | |
| SCHEMBL5489026 | 0.77 | LCK (0.55) | LCKKDRJAK3MAPK14DHFR | |
| SCHEMBL5504803 | 0.75 | MAPK14 (0.55) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL16676911 | 0.75 | FGFR4 (0.66) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL17803857 | 0.75 | LCK (0.62) | LCKKDRJAK3MAPK14ADORA1 | |
| SCHEMBL24336001 | 0.74 | BRAF (0.55) | LCKKDRJAK3MAPK14ADORA1 | |
| SCHEMBL24457804 | 0.73 | BRAF (0.47) | LCKKDRJAK3MAPK14DHFR | |
| SCHEMBL21153337 | 0.73 | FGFR4 (0.57) | LCKKDRJAK3MAPK14KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3395814-B1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | BLUEPRINT MEDICINES CORP (US) | 2022-04-06 | — | — | EP | disclosed |