Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.32 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2433357 | 0.90 | GRM4 (0.32) | GRM4 | |
| SCHEMBL2433595 | 0.89 | GRM4 (0.36) | MAPTGRM4RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2431208 | 0.89 | MAPT (0.36) | MAPTGRM4RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2435967 | 0.84 | NPSR1 (0.39) | MAPTRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2431182 | 0.84 | ADORA2B (0.35) | MAPTRAB9ANPC1SMN1; SMN2KDM5A | |
| SCHEMBL2428555 | 0.79 | GRM4 (0.31) | GRM4 | |
| SCHEMBL3807257 | 0.79 | KDM4E (0.39) | MAPTRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2429131 | 0.78 | GRM4 (0.33) | GRM4HTT | |
| SCHEMBL2432670 | 0.77 | PTPN1 (0.46) | MAPTGRM4RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2432673 | 0.77 | PTPN1 (0.46) | MAPTGRM4RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086966-B1 | 2-CARBOXY THIOPHENE DERIVATIVES AS ANTI VIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2011-09-14 | — | — | EP | claimed |