Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 17/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.57 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 5/20 | 0.52 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | NEK4 | P51957 | 2/20 | 0.50 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.50 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.50 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.50 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.50 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.50 |
| ▸ | PRKCG | P05129 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24336345 | 0.89 | ROCK2 (0.57) | AKT1ROCK2CDK2RPS6KA5GSK3B | |
| SCHEMBL21848086 | 0.88 | ROCK2 (0.65) | AKT1ROCK2CDK2RPS6KA5GSK3B | |
| SCHEMBL21848089 | 0.88 | ROCK2 (0.65) | AKT1ROCK2CDK2RPS6KA5GSK3B | |
| SCHEMBL21848065 | 0.88 | ROCK2 (0.58) | AKT1ROCK2CDK2RPS6KA5GSK3B | |
| SCHEMBL21848062 | 0.88 | ROCK2 (0.58) | AKT1ROCK2CDK2RPS6KA5GSK3B | |
| SCHEMBL24335890 | 0.85 | AKT1 (0.60) | AKT1ROCK2UTS2RCDK2RPS6KA5 | |
| SCHEMBL22077629 | 0.81 | ROCK2 (0.53) | AKT1ROCK2CDK2RPS6KA5GSK3B | |
| SCHEMBL22077628 | 0.81 | ROCK2 (0.53) | AKT1ROCK2CDK2RPS6KA5GSK3B | |
| SCHEMBL28265491 | 0.81 | ROCK2 (0.65) | AKT1ROCK2CDK2RPS6KA5GSK3B | |
| SCHEMBL21848085 | 0.80 | AKT1 (0.59) | AKT1ROCK2CDK2ROCK1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220119350-A1 | COMPOUNDS FOR THE TREATMENT OF OCULAR DISEASE | GLAUKOS CORPORATION | 2022-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220119350-A1 | COMPOUNDS FOR THE TREATMENT OF OCULAR DISEASE | ALDH1A2, SQOR, EYA3 | AKT1 2967/4885ROCK2 769/4885UTS2R 391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.