Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 4/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25606910 | 0.86 | BCAT2 (0.42) | BCAT2PDPK1HPGDKDM4ELMNA | |
| SCHEMBL24338957 | 0.80 | KDM4E (0.54) | BCAT2HPGDKDM4ELMNAGAA | |
| SCHEMBL24338103 | 0.79 | POLB (0.43) | BCAT2PDPK1HPGDKDM4ELMNA | |
| SCHEMBL13958247 | 0.71 | BCAT2 (0.46) | BCAT2PDPK1HPGDKDM4ELMNA | |
| SCHEMBL354546 | 0.69 | PARP1 (0.41) | BCAT2PDPK1HPGDKDM4ELMNA | |
| SCHEMBL19119395 | 0.67 | BCAT2 (0.76) | BCAT2PDPK1HPGDKDM4ELMNA | |
| SCHEMBL29812517 | 0.65 | GDA (0.41) | BCAT2PDPK1HPGDKDM4ELMNA | |
| SCHEMBL3866807 | 0.64 | PARP1 (0.42) | BCAT2PDPK1LMNAGAAALDH1A1 | |
| SCHEMBL9585465 | 0.64 | KDM4E (0.33) | KDM4EPOLBTRPA1ACVR1 | |
| SCHEMBL24338729 | 0.63 | TRPA1 (0.49) | LMNATRPA1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4228756-B1 | TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2024-06-12 | — | — | EP | disclosed |
| EP-4228756-A1 | TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2023-08-23 | — | — | EP | disclosed |
| CN-116249535-A | Tetrazole derivatives as TRPA1 inhibitors | 勃林格殷格翰国际有限公司 | 2023-06-09 | — | — | CN | disclosed |
| US-11661427-B2 | Tetrazole derivatives as TRPA1 inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2023-05-30 | — | — | US | disclosed |
| US-11661427-B2 | Tetrazole derivatives as TRPA1 inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2023-05-30 | — | — | US | disclosed |
| US-11661427-B2 | Tetrazole derivatives as TRPA1 inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2023-05-30 | — | — | US | disclosed |
| WO-2022079092-A1 | TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-04-21 | — | — | WO | disclosed |
| WO-2022079092-A1 | TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-04-21 | — | — | WO | disclosed |
| US-20220112202-A1 | TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220112202-A1 | TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS | TRPA1, TRPV1, TRPV5 | BCAT2 3205/4885PDPK1 999/4885HPGD 3408/4885 |
| US-11661427-B2 | Tetrazole derivatives as TRPA1 inhibitors | TRPA1, TRPV1, TRPV5 | BCAT2 3132/4885PDPK1 1015/4885HPGD 3401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.