Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.53 |
| ▸ | HCK | P08631 | 1/20 | 0.47 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 8/20 | 0.46 |
| ▸ | MET | P08581 | 8/20 | 0.46 |
| ▸ | TEK | Q02763 | 8/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2432193 | 0.91 | KDR (0.56) | KDRLCKMETTEKFLT1 | |
| SCHEMBL2437252 | 0.90 | RAF1 (0.53) | KDRHCKNR2C2LCKMET | |
| SCHEMBL2435014 | 0.87 | KDR (0.52) | KDRLCKMETTEKFLT1 | |
| SCHEMBL2435957 | 0.85 | KDR (0.62) | KDRLCKMETTEKFLT1 | |
| SCHEMBL2435232 | 0.84 | KDR (0.54) | KDRLCKMETTEK | |
| SCHEMBL2434058 | 0.83 | KDR (0.53) | KDRLCKMETTEK | |
| SCHEMBL2435966 | 0.83 | KDR (0.57) | KDRMETFLT1FLT4BRAF | |
| SCHEMBL22528714 | 0.78 | KDR (0.70) | KDRFLT1FLT4BRAFMAPK14 | |
| SCHEMBL2706559 | 0.78 | KDR (0.46) | KDRLCKMETTEK | |
| SCHEMBL2437406 | 0.77 | KDR (0.63) | KDRFLT1FLT4BRAFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |