Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 10/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 10/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.45 |
| ▸ | MEN1 | O00255 | 6/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24344785 | 0.88 | TDP1 (0.48) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL25725402 | 0.83 | TDP1 (0.44) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL14090944 | 0.82 | C3AR1 (0.52) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL14090946 | 0.81 | C3AR1 (0.47) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL24343400 | 0.79 | CA1 (0.51) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL24344786 | 0.79 | DHFR (0.46) | TDP1ATMPOLB | |
| SCHEMBL24344795 | 0.78 | TDP1 (0.36) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL25297663 | 0.78 | MEN1 (0.51) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL7541966 | 0.78 | TDP1 (0.48) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL7538486 | 0.78 | TDP1 (0.48) | TDP1ATMNPSR1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118613484-A | Antifolate linker-drug and antibody-drug conjugates | 拜奥迪斯私人有限公司 | 2024-09-06 | — | — | CN | disclosed |
| US-20230144211-A1 | ANTIFOLATE LINKER-DRUGS AND ANTIBODY-DRUG CONJUGATES | BYONDIS B.V. (NL) | 2023-05-11 | — | — | US | disclosed |
| US-20230144211-A1 | ANTIFOLATE LINKER-DRUGS AND ANTIBODY-DRUG CONJUGATES | BYONDIS B.V. (NL) | 2023-05-11 | — | — | US | disclosed |
| US-20220119392-A1 | ANTIFOLATE LINKER-DRUGS AND ANTIBODY-DRUG CONJUGATES | BYONDIS B.V. (NL) | 2022-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230144211-A1 | ANTIFOLATE LINKER-DRUGS AND ANTIBODY-DRUG CONJUGATES | DHFR, FOLR1, MTHFD2 | TDP1 3098/4885ATM 3712/4885NPSR1 3802/4885 |
| US-20220119392-A1 | ANTIFOLATE LINKER-DRUGS AND ANTIBODY-DRUG CONJUGATES | DHFR, FOLR1, MTHFD2 | TDP1 3098/4885ATM 3712/4885NPSR1 3802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.