Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 2/20 | 0.44 |
| ▸ | C1R | P00736 | 3/20 | 0.43 |
| ▸ | PYGL | P06737 | 5/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 3/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | GALK1 | P51570 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2430157 | 0.82 | PTGS2 (0.52) | CXCL8C1RPTGS2ITGB1ITGA4 | |
| SCHEMBL2429568 | 0.80 | ITGB1 (0.46) | CXCL8C1RLCKITGB1ITGA4 | |
| SCHEMBL2435428 | 0.80 | KCNH2 (0.43) | C1RITGB1ITGA4 | |
| SCHEMBL14592204 | 0.78 | ITGB1 (0.45) | C1RPTGS2ITGB1ITGA4 | |
| SCHEMBL2433113 | 0.78 | C1R (0.46) | CXCL8C1RITGB1ITGA4 | |
| SCHEMBL2432218 | 0.77 | ITGB1 (0.46) | C1RITGB1ITGA4 | |
| SCHEMBL2437908 | 0.77 | ITGB1 (0.46) | C1RITGB1ITGA4 | |
| SCHEMBL2432119 | 0.69 | ITGB1 (0.45) | C1RPTGS2GALK1ITGB1ITGA4 | |
| SCHEMBL27578612 | 0.68 | C1R (0.38) | C1RITGB1ITGA4 | |
| SCHEMBL1679090 | 0.68 | CXCL8 (0.56) | CXCL8PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1346982-B1 | VLA-4 INHIBITORS | DAIICHI SEIYAKU CO (JP) | 2011-09-14 | — | — | EP | disclosed |