Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL628707 | 1.00 | TSHR (0.54) | TSHRLMNAF2ALDH1A1TDP1 | |
| SCHEMBL23945318 | 1.00 | TSHR (0.54) | TSHRLMNAF2ALDH1A1TDP1 | |
| SCHEMBL28182671 | 0.87 | LMNA (0.61) | TSHRLMNAF2ALDH1A1TDP1 | |
| SCHEMBL72654 | 0.83 | TSHR (0.58) | TSHRLMNAF2ALDH1A1TDP1 | |
| SCHEMBL17714426 | 0.82 | TSHR (0.57) | TSHRLMNAF2ALDH1A1TDP1 | |
| SCHEMBL3234177 | 0.82 | TSHR (0.57) | TSHRLMNAF2ALDH1A1TDP1 | |
| SCHEMBL2971855 | 0.81 | LMNA (0.54) | TSHRLMNAF2ALDH1A1TDP1 | |
| SCHEMBL28041527 | 0.81 | TSHR (0.47) | TSHRLMNAALDH1A1TDP1HSD17B10 | |
| Benzoic Acid Vinyl Ester SCHEMBL28299446 | 0.80 | TSHR (0.50) | TSHRLMNAF2ALDH1A1TDP1 | |
| SCHEMBL27757178 | 0.80 | TSHR (0.50) | TSHRLMNAF2ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9279085-B2 | Method for the production of monofunctionalized dialkylphosphinic acids, esters and salts, and use thereof | CLARIANT FINANCE (BVI) LIMITED (VG) | 2016-03-08 | — | — | US | claimed |
| US-8735476-B2 | Method for producing mono-carboxy-functionalized dialkylphosphinic acids, esters and salts using a vinyl ester of a carboxylic acid and the use thereof | CLARIANT FINANCE (BVI) LIMITED (VG) | 2014-05-27 | — | — | US | claimed |
| EP-2373667-B1 | METHOD FOR PRODUCING MONO-CARBOXY-FUNCTIONALIZED DIALKYLPHOSPHINIC ACIDS, ESTERS AND SALTS USING A VINYL ESTER OF A CARBOXYLIC ACID AND THE USE THEREOF | CLARIANT FINANCE BVI LTD (VG) | 2013-12-11 | — | — | EP | claimed |
| US-20110237721-A1 | Method for Producing Mono-Carboxy-Functionalized Dialkylphosphinic Acids, Esters and Salts Using a Vinyl Ester of a Carboxylic Acid and the Use Thereof | CLARIANT FINANCE (BVI) LIMITED (VG) | 2011-09-29 | — | — | US | claimed |
| EP-2726202-B1 | METHOD FOR THE PREPARATION OF PALLADIUM(I) TRI-TERT-BUTYLPHOSPHINE BROMIDE DIMER | UMICORE AG & CO KG (DE) | 2018-05-16 | — | — | EP | disclosed |
| US-9279085-B2 | Method for the production of monofunctionalized dialkylphosphinic acids, esters and salts, and use thereof | CLARIANT FINANCE (BVI) LIMITED (VG) | 2016-03-08 | — | — | US | disclosed |
| US-9192927-B2 | Method for the preparation of palladium(I) tri-tert-butylphosphine bromide dimer and process for its use in isomerization reactions | UMICORE AG & CO. KG (DE) | 2015-11-24 | — | — | US | disclosed |
| US-20140187803-A1 | Method for the Preparation of Palladium(I) Tri-Tert-Butylphosphine Bromide Dimer and Process for its Use in Isomerization Reactions | UMICORE AG & CO. KG (DE) | 2014-07-03 | — | — | US | disclosed |
| US-8735476-B2 | Method for producing mono-carboxy-functionalized dialkylphosphinic acids, esters and salts using a vinyl ester of a carboxylic acid and the use thereof | CLARIANT FINANCE (BVI) LIMITED (VG) | 2014-05-27 | — | — | US | disclosed |
| EP-2726202-A1 | METHOD FOR THE PREPARATION OF PALLADIUM(I) TRI-TERT-BUTYLPHOSPHINE BROMIDE DIMER AND PROCESS FOR ITS USE IN ISOMERIZATION REACTIONS | Umicore AG & Co. KG (DE) | 2014-05-07 | — | — | EP | disclosed |
| WO-2013000874-A1 | METHOD FOR THE PREPARATION OF PALLADIUM(I) TRI-TERT-BUTYLPHOSPHINE BROMIDE DIMER AND PROCESS FOR ITS USE IN ISOMERIZATION REACTIONS | UMICORE AG & CO. KG (DE) | 2013-01-03 | — | — | WO | disclosed |
| US-20110251315-A1 | Method for the Production of Monofunctionalized Dialkylphosphinic Acids, Esters and Salts, and Use Thereof | CLARIANT FINANCE (BVI) LIMITED (VG) | 2011-10-13 | — | — | US | disclosed |
| EP-1268493-B1 | PHOSPHORAMIDATE PRODRUGS | PURDUE RESEARCH FOUNDATION (US) | 2006-02-15 | — | — | EP | disclosed |
| US-20050171060-A1 | Phosphoramidates and methods therefor | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-08-04 | — | — | US | disclosed |
| US-6903081-B2 | Phosphoramidates and methods therefor | PURDUE RESEARCH FOUNDATION (US) | 2005-06-07 | — | — | US | disclosed |
| EP-1268493-A1 | PHOSPHORAMIDATE PRODRUGS | PURDUE RESEARCH FOUNDATION (US) | 2003-01-02 | — | — | EP | disclosed |
| US-20020004594-A1 | Phosphoramidates and methods therefor | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-01-10 | — | — | US | disclosed |
| WO-2001074827-A1 | PHOSPHORAMIDATE PRODRUGS | PURDUE RESEARCH FOUNDATION (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-0513331-A1 | AZEOTROPIC ASSISTED TRANSVINYLATION TECHNOLOGY | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) | 1992-11-19 | — | — | EP | disclosed |
| WO-1992009554-A1 | AZEOTROPIC ASSISTED TRANSVINYLATION TECHNOLOGY | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) | 1992-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140187803-A1 | Method for the Preparation of Palladium(I) Tri-Tert-Butylphosphine Bromide Dimer and Process for its Use in Isomerization Reactions | CBR3, TRRAP, TERB1 | TSHR 78/4885LMNA 3260/4885F2 940/4885 |
| US-20020004594-A1 | Phosphoramidates and methods therefor | WEE1, HASPIN, WEE2 | TSHR 3813/4885LMNA 3858/4885F2 4652/4885 |
| US-20110237721-A1 | Method for Producing Mono-Carboxy-Functionalized Dialkylphosphinic Acids, Esters and Salts Using a Vinyl Ester of a Carboxylic Acid and the Use Thereof | SCO2, HAO2, DAO | TSHR 1600/4885LMNA 2720/4885F2 502/4885 |
| US-20110251315-A1 | Method for the Production of Monofunctionalized Dialkylphosphinic Acids, Esters and Salts, and Use Thereof | LPAR6, LPAR2, HAO2 | TSHR 83/4885LMNA 3960/4885F2 1559/4885 |
| US-20050171060-A1 | Phosphoramidates and methods therefor | WEE1, HASPIN, WEE2 | TSHR 3813/4885LMNA 3858/4885F2 4652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.