Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31158400 | 1.00 | MAPT (0.49) | MAPTTP53LMNAHDAC1HDAC2 | |
| SCHEMBL24359484 | 0.84 | MAPT (0.67) | MAPTLMNAHDAC1HDAC2HDAC8 | |
| SCHEMBL24359485 | 0.78 | LMNA (0.55) | MAPTLMNANPC1ADORA2ARAB9A | |
| SCHEMBL24359720 | 0.76 | ALDH1A1 (0.61) | MAPTLMNAHDAC1HDAC2HDAC8 | |
| SCHEMBL29516047 | 0.76 | ALDH1A1 (0.61) | MAPTLMNAHDAC1HDAC2HDAC8 | |
| SCHEMBL29516298 | 0.73 | MAOB (0.52) | MAPTHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL24359463 | 0.73 | MAOB (0.52) | MAPTHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL24359609 | 0.72 | HDAC1 (0.69) | MAPTHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL185171 | 0.71 | DYRK1A (0.60) | POLBNPC1ADORA1RAB9ASMN1; SMN2 | |
| SCHEMBL24142457 | 0.69 | ALDH1A1 (0.49) | MAPTTP53LMNAPOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022087456-A1 | NEW COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-04-28 | — | — | WO | disclosed |