Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.52 |
| ▸ | KDM4A | O75164 | 1/20 | 0.52 |
| ▸ | KDM4B | O94953 | 1/20 | 0.52 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.52 |
| ▸ | CCR6 | P51684 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29516047 | 1.00 | ALDH1A1 (0.61) | ALDH1A1MAPTKDM4EPOLBGAA | |
| SCHEMBL24359609 | 0.87 | HDAC1 (0.69) | ALDH1A1MAPTPKMALOX15HDAC3 | |
| SCHEMBL29516051 | 0.81 | ALDH1A1 (0.66) | ALDH1A1MAPTKDM4EPOLBGAA | |
| SCHEMBL24359376 | 0.81 | ALDH1A1 (0.66) | ALDH1A1MAPTKDM4EPOLBGAA | |
| SCHEMBL24359485 | 0.76 | LMNA (0.55) | ALDH1A1MAPTLMNAHPGDMEN1 | |
| SCHEMBL24359484 | 0.76 | MAPT (0.67) | ALDH1A1MAPTKDM4EPOLBLMNA | |
| SCHEMBL31158400 | 0.76 | MAPT (0.49) | MAPTPOLBGAATDP1LMNA | |
| SCHEMBL24359481 | 0.76 | MAPT (0.49) | MAPTPOLBGAATDP1LMNA | |
| SCHEMBL29516403 | 0.74 | ALDH1A1 (0.67) | ALDH1A1MAPTKDM4EPOLBGAA | |
| SCHEMBL21241884 | 0.74 | ALDH1A1 (0.68) | ALDH1A1MAPTKDM4EPOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022087456-A1 | NEW COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-04-28 | — | — | WO | disclosed |