Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 1/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | CIT | O14578 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.43 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.43 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28685463 | 0.85 | CYP1A2 (0.49) | PSMB8CYP1A2CDC7CITPIM1 | |
| SCHEMBL374150 | 0.76 | SOS1 (0.51) | PSMB8PSMB5PIK3CGSOS1ALDH1A1 | |
| SCHEMBL12649101 | 0.76 | CHRNB2 (0.54) | CYP1A2LMNANR1H4CHRNB2CHRNA4 | |
| SCHEMBL28901281 | 0.76 | CHRNB2 (0.54) | CYP1A2LMNANR1H4CHRNB2CHRNA4 | |
| SCHEMBL28901276 | 0.76 | CHRNB2 (0.54) | CYP1A2LMNANR1H4CHRNB2CHRNA4 | |
| SCHEMBL10117351 | 0.72 | CHRNB2 (0.37) | CYP1A2NR1H4CHRNB2CHRNA4CYP2D6 | |
| SCHEMBL38656052 | 0.72 | GPR119 (0.41) | PIK3CGPIM1ALDH1A1MEN1KMT2A | |
| SCHEMBL38657073 | 0.72 | GPR119 (0.41) | PIK3CGPIM1ALDH1A1MEN1KMT2A | |
| SCHEMBL28686943 | 0.71 | MPO (0.60) | CYP1A2CDC7CITPIM1CSNK2A2 | |
| SCHEMBL15944074 | 0.71 | PIK3CG (0.42) | PSMB8PSMB5PIK3CGSOS1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022084448-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | EVOTEC INTERNATIONAL GMBH (DE) | 2022-04-28 | — | — | WO | disclosed |