Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.47 |
| ▸ | TAF1 | P21675 | 3/20 | 0.47 |
| ▸ | CECR2 | Q9BXF3 | 3/20 | 0.47 |
| ▸ | BRD9 | Q9H8M2 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19651852 | 0.91 | BRD4 (0.48) | BRD4TAF1CECR2BRD9KMT2A | |
| SCHEMBL19657115 | 0.83 | BRD4 (0.50) | BRD4TAF1CECR2BRD9KMT2A | |
| SCHEMBL19651854 | 0.77 | HSP90AA1 (0.46) | BRD4TAF1CECR2BRD9KMT2A | |
| SCHEMBL19657105 | 0.68 | CECR2 (0.47) | BRD4TAF1CECR2BRD9NPC1 | |
| SCHEMBL14094387 | 0.68 | KMT2A (0.65) | KMT2AMEN1NPC1RAB9AHSP90AA1 | |
| SCHEMBL19651856 | 0.68 | HSP90AB1 (0.46) | BRD4TAF1CECR2BRD9KMT2A | |
| SCHEMBL29482218 | 0.67 | RORC (0.40) | BRD4TAF1CECR2BRD9KMT2A | |
| SCHEMBL17758611 | 0.67 | RORC (0.40) | BRD4TAF1CECR2BRD9KMT2A | |
| SCHEMBL12569940 | 0.66 | L3MBTL1 (0.56) | KMT2AMEN1NPC1RAB9AHSP90AA1 | |
| SCHEMBL7361803 | 0.65 | HDAC1 (0.46) | BRD9KMT2AMEN1NPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3218375-B1 | SUBSTITUTED PYRROLOPYRDINES AS INHIBITORS OF BROMODOMAIN | GENENTECH INC (US) | 2022-04-27 | — | — | EP | disclosed |