SCHEMBL2437221

SCHEMBL2437221

O=C(Nc1noc2ccccc12)Oc1csc2ccccc12

nearest known ligand 0.47

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 7/20 0.47
TP53 P04637 6/20 0.47
MAPT P10636 1/20 0.46
ALOX15 P16050 1/20 0.43
TSHR P16473 1/20 0.43
KCNJ6 P48051 1/20 0.43
KCNJ3 P48549 1/20 0.43
FAAH O00519 5/20 0.42
ALDH1A1 P00352 1/20 0.39
LMNA P02545 1/20 0.39
HPGD P15428 1/20 0.39
HIF1A Q16665 3/20 0.39
PKM P14618 1/20 0.38
EPHX2 P34913 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2445067 0.79 TP53 (0.50) SMN1; SMN2TP53MAPTALOX15TSHR
SCHEMBL896377 0.78 TP53 (0.56) SMN1; SMN2TP53MAPTALOX15TSHR
SCHEMBL2443219 0.72 EPHX2 (0.54) SMN1; SMN2TP53MAPTALOX15TSHR
SCHEMBL2442920 0.72 SMN1; SMN2 (0.50) SMN1; SMN2TP53MAPTALOX15TSHR
SCHEMBL12636152 0.71 TP53 (0.55) SMN1; SMN2TP53MAPTALOX15TSHR
SCHEMBL7089986 0.71 SMN1; SMN2 (0.63) SMN1; SMN2TP53MAPTALOX15TSHR
SCHEMBL5164703 0.69 HDAC3 (0.46) SMN1; SMN2MAPTALOX15ALDH1A1LMNA
SCHEMBL7032384 0.68 PKM (0.53) SMN1; SMN2TP53MAPTALOX15ALDH1A1
SCHEMBL573398 0.68 SMN1; SMN2 (0.50) SMN1; SMN2TP53MAPTALOX15TSHR
SCHEMBL2440614 0.68 TP53 (0.52) SMN1; SMN2TP53MAPTALOX15TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1893589-B1 SUBSTITUTED N-BENZO [D] ISOXAZOL-3-YL-AMINE DERIVATIVES AS INHIBITORS OF MGLUR5, SEROTONINE (5-HT) AND NORADRENALINE RECEPTORS, AND THE USE THEREOF FOR PRODUCING MEDICAMENTS GRUENENTHAL GMBH (DE) 2011-09-14 EP claimed
EP-1893589-A1 SUBSTITUTED N-BENZO [D] ISOXAZOL-3-YL-AMINE DERIVATIVES AS INHIBITORS OF MGLUR5, SEROTONINE (5-HT) AND NORADRENALINE RECEPTORS, AND THE USE THEREOF FOR PRODUCING MEDICAMENTS Grünenthal GmbH (DE) 2008-03-05 EP claimed
WO-2006131296-A1 SUBSTITUTED N-BENZO [D] ISOXAZOL-3-YL-AMINE DERIVATIVES AS INHIBITORS OF MGLUR5, SEROTONINE (5-HT) AND NORADRENALINE RECEPTORS, AND THE USE THEREOF FOR PRODUCING MEDICAMENTS Grünenthal GmbH (DE) 2006-12-14 WO claimed
EP-1893589-B1 SUBSTITUTED N-BENZO [D] ISOXAZOL-3-YL-AMINE DERIVATIVES AS INHIBITORS OF MGLUR5, SEROTONINE (5-HT) AND NORADRENALINE RECEPTORS, AND THE USE THEREOF FOR PRODUCING MEDICAMENTS GRUENENTHAL GMBH (DE) 2011-09-14 EP disclosed
EP-1893589-A1 SUBSTITUTED N-BENZO [D] ISOXAZOL-3-YL-AMINE DERIVATIVES AS INHIBITORS OF MGLUR5, SEROTONINE (5-HT) AND NORADRENALINE RECEPTORS, AND THE USE THEREOF FOR PRODUCING MEDICAMENTS Grünenthal GmbH (DE) 2008-03-05 EP disclosed
WO-2006131296-A1 SUBSTITUTED N-BENZO [D] ISOXAZOL-3-YL-AMINE DERIVATIVES AS INHIBITORS OF MGLUR5, SEROTONINE (5-HT) AND NORADRENALINE RECEPTORS, AND THE USE THEREOF FOR PRODUCING MEDICAMENTS Grünenthal GmbH (DE) 2006-12-14 WO disclosed