Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGDS | O60760 | 3/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | F3 | P13726 | 1/20 | 0.37 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.37 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1244783 | 0.80 | SMN1; SMN2 (0.56) | NNMTSMN1; SMN2MKNK1MKNK2L3MBTL1 | |
| SCHEMBL12855306 | 0.77 | NNMT (0.46) | NNMTSMN1; SMN2MKNK1MKNK2PARP1 | |
| SCHEMBL3407188 | 0.76 | NNMT (0.56) | NNMTSMN1; SMN2MKNK1MKNK2L3MBTL1 | |
| SCHEMBL534160 | 0.75 | NPC1 (0.50) | SMN1; SMN2KDM4EMAPTHSD17B10MEN1 | |
| SCHEMBL323980 | 0.75 | CA2 (0.53) | MKNK1MKNK2L3MBTL1MAPTHSD17B10 | |
| SCHEMBL55043 | 0.74 | — | — | |
| SCHEMBL30033603 | 0.72 | AR (0.49) | NNMTSMN1; SMN2MKNK1MKNK2L3MBTL1 | |
| SCHEMBL533702 | 0.71 | HDAC4 (0.40) | SMN1; SMN2KDM4EHPGDSMAPTHSD17B10 | |
| SCHEMBL12499609 | 0.71 | HDAC4 (0.40) | SMN1; SMN2KDM4EHPGDSMAPTHSD17B10 | |
| SCHEMBL534059 | 0.71 | NPC1 (0.46) | SMN1; SMN2KDM4EHPGDSMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364296-A1 | PYRROLIDINES | Pfizer Limited (GB) | 2011-09-14 | — | — | EP | disclosed |
| WO-2010052625-A1 | PYRROLIDINES | PFIZER LIMITED (GB) | 2010-05-14 | — | — | WO | disclosed |