Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.69 |
| ▸ | TSHR | P16473 | 3/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.69 |
| ▸ | RECQL | P46063 | 1/20 | 0.69 |
| ▸ | GFER | P55789 | 1/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | S100B | P04271 | 1/20 | 0.40 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.39 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.39 |
| ▸ | ESRRG | P62508 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29740663 | 0.92 | ALDH1A1 (0.82) | ALDH1A1CYP3A4TDP1L3MBTL1TSHR | |
| SCHEMBL4717774 | 0.90 | ALDH1A1 (0.58) | ALDH1A1CYP3A4TDP1L3MBTL1TSHR | |
| SCHEMBL14596279 | 0.84 | ALDH1A1 (0.69) | ALDH1A1CYP3A4TDP1L3MBTL1TSHR | |
| SCHEMBL7520164 | 0.83 | ALDH1A1 (0.75) | ALDH1A1CYP3A4TDP1L3MBTL1TSHR | |
| SCHEMBL33781 | 0.83 | ALDH1A1 (1.00) | ALDH1A1CYP3A4TDP1L3MBTL1TSHR | |
| SCHEMBL8467252 | 0.83 | ALDH1A1 (1.00) | ALDH1A1CYP3A4TDP1L3MBTL1TSHR | |
| SCHEMBL6389743 | 0.82 | ALDH1A1 (0.72) | ALDH1A1CYP3A4TDP1L3MBTL1TSHR | |
| SCHEMBL19496234 | 0.82 | ALDH1A1 (0.44) | ALDH1A1CYP3A4TDP1L3MBTL1TSHR | |
| Hydrochloric Acid SCHEMBL970321 | 0.81 | ALDH1A1 (0.95) | ALDH1A1CYP3A4TDP1L3MBTL1TSHR | |
| Hydrochloric Acid SCHEMBL970320 | 0.81 | ALDH1A1 (0.95) | ALDH1A1CYP3A4TDP1L3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552211-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | Glaxo Group Limited (GB) | 2013-02-06 | — | — | EP | disclosed |
| US-20130023532-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-24 | — | — | US | disclosed |
| WO-2011120025-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2011-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130023532-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | MAP3K19, MAP3K1, MAP3K20 | ALDH1A1 1337/4885CYP3A4 3598/4885TDP1 606/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.