Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 11/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 10/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 8/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 5/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27101309 | 0.78 | ALDH1A1 (0.45) | NPC1RAB9AMEN1KMT2ACYP3A4 | |
| SCHEMBL29622084 | 0.77 | HTT (0.42) | PDK2MEN1KMT2APDK4PDK1 | |
| SCHEMBL17732010 | 0.77 | PDE4B (0.53) | MEN1KMT2ACYP3A4ALDH1A1SMN1; SMN2 | |
| SCHEMBL22778854 | 0.77 | XDH (0.41) | NPC1RAB9AMEN1KMT2ACYP3A4 | |
| SCHEMBL17731964 | 0.77 | HSD17B14 (0.42) | NPC1RAB9AMEN1KMT2ACYP3A4 | |
| SCHEMBL24376588 | 0.74 | PDK2 (0.54) | PDK2HSP90AA1NPC1MEN1KMT2A | |
| SCHEMBL1061912 | 0.71 | ALDH1A1 (0.50) | NPC1RAB9AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL25268811 | 0.70 | HPGD (0.53) | ALDH1A1POLB | |
| SCHEMBL20486918 | 0.70 | CES2 (0.48) | RAB9AMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL30481570 | 0.70 | HPGD (0.53) | ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022086937-A9 | HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF ENL | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2023-02-02 | — | — | WO | disclosed |
| WO-2022086937-A1 | HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF ENL | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-04-28 | — | — | WO | disclosed |