⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24379143 | 0.81 | ADAM17 (0.41) | — | |
| SCHEMBL24379420 | 0.79 | CRBN (0.32) | — | |
| SCHEMBL24379148 | 0.76 | CRBN (0.31) | — | |
| SCHEMBL24379145 | 0.76 | CRBN (0.31) | — | |
| SCHEMBL20128628 | 0.73 | CRBN (0.51) | — | |
| SCHEMBL20128651 | 0.72 | — | — | |
| SCHEMBL24379149 | 0.71 | CRBN (0.38) | — | |
| SCHEMBL24379147 | 0.69 | CRBN (0.56) | — | |
| SCHEMBL24379153 | 0.69 | CRBN (0.56) | — | |
| SCHEMBL24379144 | 0.69 | CRBN (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022087125-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR PROTEIN | ARVINAS OPERATIONS, INC. (US) | 2022-04-28 | — | — | WO | disclosed |