Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.31 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24379425 | 0.80 | ALDH1A1 (0.33) | CRBNDDB1ALDH1A1 | |
| SCHEMBL24379424 | 0.80 | CDC25B (0.31) | CRBNDDB1ALDH1A1 | |
| SCHEMBL24379155 | 0.79 | — | — | |
| SCHEMBL31557838 | 0.77 | CRBN (0.53) | CRBNDDB1ALDH1A1 | |
| SCHEMBL14511569 | 0.77 | CRBN (0.53) | CRBNDDB1ALDH1A1 | |
| SCHEMBL20812351 | 0.77 | CRBN (0.53) | CRBNDDB1ALDH1A1 | |
| SCHEMBL24379064 | 0.77 | CRBN (0.53) | CRBNDDB1ALDH1A1 | |
| SCHEMBL24379421 | 0.77 | CRBN (0.53) | CRBNDDB1ALDH1A1 | |
| SCHEMBL24379423 | 0.76 | ABCC9 (0.40) | CRBNLMNADDB1ALDH1A1 | |
| SCHEMBL24379143 | 0.73 | ADAM17 (0.41) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022087125-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR PROTEIN | ARVINAS OPERATIONS, INC. (US) | 2022-04-28 | — | — | WO | disclosed |