Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 13/20 | 0.56 |
| ▸ | ITGA4 | P13612 | 13/20 | 0.56 |
| ▸ | IDO1 | P14902 | 3/20 | 0.36 |
| ▸ | TDO2 | P48775 | 3/20 | 0.36 |
| ▸ | MET | P08581 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2437991 | 1.00 | ITGB1 (0.56) | ITGB1ITGA4IDO1TDO2MET | |
| SCHEMBL2432988 | 0.95 | ITGB1 (0.55) | ITGB1ITGA4IDO1TDO2MET | |
| SCHEMBL2432986 | 0.95 | ITGB1 (0.55) | ITGB1ITGA4IDO1TDO2MET | |
| SCHEMBL2434329 | 0.93 | ITGB1 (0.64) | ITGB1ITGA4METPDCD1CD274 | |
| SCHEMBL2434330 | 0.93 | ITGB1 (0.64) | ITGB1ITGA4METPDCD1CD274 | |
| SCHEMBL2432878 | 0.93 | ITGB1 (0.56) | ITGB1ITGA4METNPC1HSP90AA1 | |
| SCHEMBL2432880 | 0.93 | ITGB1 (0.56) | ITGB1ITGA4METNPC1HSP90AA1 | |
| SCHEMBL2432155 | 0.91 | ITGB1 (0.52) | ITGB1ITGA4METPDCD1CD274 | |
| SCHEMBL2434259 | 0.90 | ITGA4 (0.54) | ITGB1ITGA4METPDCD1CD274 | |
| SCHEMBL2436543 | 0.88 | ITGB1 (0.63) | ITGB1ITGA4METPDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1346982-B1 | VLA-4 INHIBITORS | DAIICHI SEIYAKU CO (JP) | 2011-09-14 | — | — | EP | disclosed |
| US-7157487-B2 | Vla-4 inhibitors | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2007-01-02 | — | — | US | disclosed |
| US-20040110945-A1 | Vla-4 inhibitors | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2004-06-10 | — | — | US | disclosed |
| EP-1346982-A1 | VLA-4 INHIBITORS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2003-09-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110945-A1 | Vla-4 inhibitors | VCAM1, ITGA1, ITGB4 | ITGB1 5/4885ITGA4 4/4885IDO1 1371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.