Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 3/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.36 |
| ▸ | PDE2A | O00408 | 3/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | RET | P07949 | 2/20 | 0.35 |
| ▸ | KIF5B | P33176 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
| ▸ | LITAF | Q99732 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24392237 | 0.82 | PDE10A (0.41) | PDE1BPDE5APDE10APDE2APDE4D | |
| SCHEMBL24392596 | 0.78 | PIK3CA (0.43) | PDE5APDE10APDE2APDE4DRET | |
| SCHEMBL12141928 | 0.77 | PDE5A (0.62) | PDE1BPDE5A | |
| SCHEMBL24392592 | 0.77 | ALDH1A1 (0.48) | PDE1BPDE5APDE10APDE2ATNF | |
| SCHEMBL22644982 | 0.75 | PDE1B (0.48) | PDE1BPDE5ATNFLITAFEGFR | |
| SCHEMBL24392135 | 0.73 | TRPA1 (0.48) | PDE1BPDE10ARETKIF5BKDR | |
| SCHEMBL11316949 | 0.71 | PDE1B (0.58) | PDE1BPDE10ARETKDREGFR | |
| SCHEMBL12141932 | 0.71 | PDE1B (0.61) | PDE1BPDE5APDE10APDE2APDE4D | |
| SCHEMBL24392126 | 0.71 | PDE1B (0.48) | PDE1BRETKIF5BKDREGFR | |
| SCHEMBL21442344 | 0.70 | PDGFRB (0.38) | EGFRTRPA1KCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220135598-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE-1 (ENPP1) INHIBITORS AND USES THEREOF | INTEGRAL BIOSCIENCES PRIVATE LIMITED (IN) | 2022-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220135598-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE-1 (ENPP1) INHIBITORS AND USES THEREOF | ENPP1, ENPP3, ENPP2 | PDE1B 37/4885PDE5A 13/4885PDE10A 111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.