SCHEMBL24401393

SCHEMBL24401393

C=CNCCCC[C@H](NC(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])C(C)C)C(=O)Nc1ccc(CO)cc1

nearest known ligand 0.36

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ FURIN P09958 5/20 0.36
▸ ROCK2 O75116 1/20 0.33
▸ KLKB1 P03952 3/20 0.32
▸ CTSL P07711 1/20 0.32
▸ ALB P02768 1/20 0.32
▸ FOLH1 Q04609 6/20 0.31
▸ SIRT5 Q9NXA8 1/20 0.31
▸ SIRT2 Q8IXJ6 2/20 0.31
▸ SIRT1 Q96EB6 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24390287 0.91 FURIN (0.38) FURINROCK2KLKB1CTSLALB
SCHEMBL26024621 0.87 FOLH1 (0.41) FOLH1
SCHEMBL29623561 0.87 FURIN (0.40) FURINROCK2CTSL
SCHEMBL29528370 0.87 FURIN (0.40) FURINROCK2CTSL
SCHEMBL30483106 0.86 FURIN (0.40) FURINROCK2KLKB1CTSL
SCHEMBL25383060 0.83 FURIN (0.37) FURINALBFOLH1SIRT5SIRT2
SCHEMBL29048536 0.83 FURIN (0.37) FURINALBFOLH1SIRT5SIRT2
SCHEMBL26027087 0.83 FURIN (0.40) FURINROCK2KLKB1CTSLALB
SCHEMBL23071953 0.82 CASP1 (0.35) FURIN
SCHEMBL22690077 0.82 CASP1 (0.35) FURIN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4257156-A2 FOLATE RECEPTOR TARGETED NANOPARTICLE DRUG CONJUGATES AND USES THEREOF Elucida Oncology, Inc. (US) 2023-10-11 — — EP disclosed
US-20230263898-A1 FOLATE RECEPTOR TARGETED NANOPARTICLE DRUG CONJUGATES AND USES THEREOF ELUCIDA ONCOLOGY, INC. 2023-08-24 — — US disclosed
US-20230263899-A1 FOLATE RECEPTOR TARGETED NANOPARTICLE DRUG CONJUGATES AND USES THEREOF ELUCIDA ONCOLOGY, INC. 2023-08-24 — — US disclosed
EP-4103236-B1 FOLATE RECEPTOR TARGETED NANOPARTICLE DRUG CONJUGATES AND USES THEREOF ELUCIDA ONCOLOGY INC (US) 2023-08-16 — — EP disclosed
US-20230021059-A1 METHODS OF FUNCTIONALIZING NANOPARTICLES ELUCIDA ONCOLOGY, INC. 2023-01-19 — — US disclosed
WO-2022093793-A1 FOLATE RECEPTOR TARGETED NANOPARTICLE DRUG CONJUGATES AND USES THEREOF ELUCIDA ONCOLOGY, INC. (US) 2022-05-05 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230263899-A1 FOLATE RECEPTOR TARGETED NANOPARTICLE DRUG CONJUGATES AND USES THEREOF FOLR1, FOLR2, DHFR FURIN 2202/4885ROCK2 1619/4885KLKB1 2964/4885
US-20230263898-A1 FOLATE RECEPTOR TARGETED NANOPARTICLE DRUG CONJUGATES AND USES THEREOF FOLR1, FOLR2, DHFR FURIN 2202/4885ROCK2 1619/4885KLKB1 2964/4885
US-20230021059-A1 METHODS OF FUNCTIONALIZING NANOPARTICLES NDC1, NCL, CD47 FURIN 1409/4885ROCK2 1353/4885KLKB1 1668/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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