Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESRRA | P11474 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | AGER | Q15109 | 1/20 | 0.33 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 2/20 | 0.32 |
| ▸ | PARG | Q86W56 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24405899 | 0.80 | PGR (0.37) | PGRAGERNPEPPSPIK3CDPIK3CA | |
| SCHEMBL24405371 | 0.76 | PGR (0.36) | PGRPIK3CDPIK3CAMTORPIK3CG | |
| SCHEMBL23616489 | 0.72 | KDM4E (0.43) | ALDH1A1TP53ATMMAPT | |
| SCHEMBL24405760 | 0.70 | MCHR1 (0.43) | PGRNPEPPSPIK3CDPIK3CAMTOR | |
| SCHEMBL23784500 | 0.69 | DNM1 (0.33) | MTORALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL24405846 | 0.69 | PGR (0.37) | PGRNPEPPSPIK3CAMTORALDH1A1 | |
| SCHEMBL6362809 | 0.69 | PGR (0.68) | PGRALDH1A1LMNASMN1; SMN2PARG | |
| SCHEMBL15082037 | 0.68 | PGR (0.53) | PGRPIK3CDPIK3CAMTORPIK3CG | |
| SCHEMBL15396388 | 0.67 | PGR (0.51) | PGRNPEPPSALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL24405685 | 0.66 | NPEPPS (0.46) | PGRNPEPPSALDH1A1SMN1; SMN2AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774739-B1 | FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST | RAQUALIA PHARMA INC (JP) | 2022-05-11 | — | — | EP | disclosed |