Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EED | O75530 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PROKR1 | Q8TCW9 | 4/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | PARG | Q86W56 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24405885 | 0.82 | PGR (0.33) | EEDPGRGRM4PARGMAP4K1 | |
| SCHEMBL1269228 | 0.80 | PGR (0.41) | PGRDYRK1AGRM4GSK3BPARG | |
| SCHEMBL1269624 | 0.78 | PGR (0.34) | PGRPOLBGRM4MAPK8MAP4K1 | |
| SCHEMBL1269274 | 0.75 | XBP1 (0.31) | PGRNPC1RAB9AMAP4K1 | |
| SCHEMBL24405904 | 0.72 | LRRK2 (0.55) | MAPK8MAP4K1PIK3CA | |
| SCHEMBL6362809 | 0.71 | PGR (0.68) | PGRMAPK8GSK3BPARGCYP1A2 | |
| SCHEMBL21474185 | 0.71 | ROCK2 (0.39) | PIK3CA | |
| SCHEMBL14094434 | 0.68 | SMN1; SMN2 (0.47) | PGRPOLBRAB9AGRM4CYP1A2 | |
| SCHEMBL24405558 | 0.68 | PGR (0.43) | PGRNPC1RAB9AGSK3BCYP1A2 | |
| SCHEMBL24405829 | 0.68 | PDE10A (0.40) | PGRGRM4GSK3BPARGMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774739-B1 | FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST | RAQUALIA PHARMA INC (JP) | 2022-05-11 | — | — | EP | disclosed |