Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | BCL6 | P41182 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | BRD1 | O95696 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | PARG | Q86W56 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24405354 | 0.76 | GSK3B (0.40) | PDE10AGRM4GSK3BMAP4K1PGR | |
| SCHEMBL24405544 | 0.76 | GSK3B (0.40) | PDE10AGSK3BMAP4K1PGRSMN1; SMN2 | |
| SCHEMBL21463401 | 0.75 | GABRP (0.56) | MAP4K1KMT2AMEN1MAPT | |
| SCHEMBL24405558 | 0.75 | PGR (0.43) | PDE10AGSK3BMAP4K1PGRKMT2A | |
| SCHEMBL24405507 | 0.73 | PDE10A (0.37) | PDE10AGSK3BMAP4K1PGRKMT2A | |
| SCHEMBL24405741 | 0.72 | GLO1 (0.41) | PDE10AGSK3BMAP4K1PGR | |
| SCHEMBL1269228 | 0.70 | PGR (0.41) | GRM4GSK3BMAP4K1PGRKMT2A | |
| SCHEMBL6362809 | 0.69 | PGR (0.68) | GSK3BPGRSMN1; SMN2KDM4EADORA3 | |
| SCHEMBL14094434 | 0.69 | SMN1; SMN2 (0.47) | PDE10AGRM4PGRSMN1; SMN2 | |
| SCHEMBL24405371 | 0.69 | PGR (0.36) | PDE10AGRM4GSK3BMAP4K1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774739-B1 | FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST | RAQUALIA PHARMA INC (JP) | 2022-05-11 | — | — | EP | disclosed |