Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.37 |
| ▸ | BRD1 | O95696 | 1/20 | 0.37 |
| ▸ | TAF1 | P21675 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24405804 | 0.81 | CYP1A2 (0.40) | MAPTALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL13376862 | 0.68 | PGR (0.64) | MAPTALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL24405665 | 0.67 | TP53 (0.53) | MAPTALDH1A1KDM4ENPSR1BRPF1 | |
| SCHEMBL29798837 | 0.66 | CYP1A2 (0.55) | ALDH1A1KDM4EHSD17B10BRPF1PGR | |
| SCHEMBL474339 | 0.66 | CYP1A2 (0.55) | ALDH1A1KDM4EHSD17B10BRPF1PGR | |
| SCHEMBL6362809 | 0.66 | PGR (0.68) | ALDH1A1KDM4EPGRLMNASMN1; SMN2 | |
| SCHEMBL24405984 | 0.65 | EED (0.45) | MAPTPGRGAARAB9ANPC1 | |
| SCHEMBL30402458 | 0.65 | GRM4 (0.45) | MAPTALDH1A1KDM4EPGRLMNA | |
| SCHEMBL24405919 | 0.64 | CYP1A2 (0.47) | MAPTALDH1A1KDM4EPGRKMT2A | |
| SCHEMBL21173494 | 0.64 | ALDH1A1 (0.53) | MAPTALDH1A1HPGDKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774739-B1 | FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST | RAQUALIA PHARMA INC (JP) | 2022-05-11 | — | — | EP | disclosed |