Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 4/20 | 0.40 |
| ▸ | JAK1 | P23458 | 4/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24409120 | 0.85 | GPR119 (0.45) | GPR119NAMPT | |
| SCHEMBL24408911 | 0.84 | POLB (0.50) | GPR119NAMPT | |
| SCHEMBL28753038 | 0.76 | GPR119 (0.47) | GPR119JAK2JAK1 | |
| SCHEMBL13161934 | 0.76 | POLB (0.48) | GPR119NAMPT | |
| SCHEMBL22520476 | 0.76 | GPR119 (0.52) | GPR119NAMPT | |
| SCHEMBL25390075 | 0.74 | GPR119 (0.49) | GPR119 | |
| SCHEMBL29634691 | 0.74 | GPR119 (0.54) | GPR119NAMPT | |
| SCHEMBL31283120 | 0.74 | GPR119 (0.49) | GPR119 | |
| SCHEMBL22582994 | 0.73 | GPR119 (0.45) | GPR119 | |
| SCHEMBL17848653 | 0.73 | GPR119 (0.54) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022095971-A1 | SPIRO HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海医药集团股份有限公司 | 2022-05-12 | — | — | WO | disclosed |
| WO-2022095971-A1 | SPIRO HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海医药集团股份有限公司 | 2022-05-12 | — | — | WO | disclosed |