Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 5/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24409120 | 0.88 | GPR119 (0.45) | POLBGPR119OPRD1OPRK1NAMPT | |
| SCHEMBL24408910 | 0.84 | GPR119 (0.47) | GPR119NAMPT | |
| SCHEMBL29634693 | 0.83 | POLB (0.49) | POLBGPR119OPRD1OPRK1HRH3 | |
| SCHEMBL24408862 | 0.83 | POLB (0.49) | POLBGPR119OPRD1OPRK1HRH3 | |
| SCHEMBL29634697 | 0.82 | TRPM8 (0.35) | HRH3 | |
| SCHEMBL24408859 | 0.79 | POLB (0.44) | POLBGPR119OPRD1OPRK1MEN1 | |
| SCHEMBL29634721 | 0.79 | POLB (0.44) | POLBGPR119OPRD1OPRK1MEN1 | |
| SCHEMBL22520476 | 0.79 | GPR119 (0.52) | GPR119NAMPTHRH3 | |
| SCHEMBL13161934 | 0.79 | POLB (0.48) | POLBGPR119OPRD1OPRK1NAMPT | |
| SCHEMBL24408874 | 0.77 | GPR119 (0.46) | POLBGPR119NAMPTHRH3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022095971-A1 | SPIRO HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海医药集团股份有限公司 | 2022-05-12 | — | — | WO | disclosed |
| WO-2022095971-A1 | SPIRO HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海医药集团股份有限公司 | 2022-05-12 | — | — | WO | disclosed |
| CN-114437096-A | Spiro-heterocyclic compound, and preparation method and application thereof | 上海医药集团股份有限公司 | 2022-05-06 | — | — | CN | disclosed |