Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | UBE2N | P61088 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12623907 | 0.88 | LMNA (0.43) | NPC1ALDH1A1SMN1; SMN2UBE2NKMT2A | |
| SCHEMBL23160703 | 0.87 | NPC1 (0.41) | NPC1HSD11B1ALDH1A1USP2SMN1; SMN2 | |
| SCHEMBL12622192 | 0.80 | ALDH1A1 (0.45) | NPC1ALDH1A1USP2SMN1; SMN2UBE2N | |
| SCHEMBL12623894 | 0.76 | ALDH1A1 (0.42) | NPC1ALDH1A1SMN1; SMN2KMT2ALMNA | |
| SCHEMBL24418076 | 0.63 | ALDH1A1 (0.42) | NPC1HSD11B1ALDH1A1USP2SMN1; SMN2 | |
| SCHEMBL12623893 | 0.62 | ALDH1A1 (0.46) | NPC1HSD11B1ALDH1A1USP2SMN1; SMN2 | |
| SCHEMBL12189230 | 0.62 | SMN1; SMN2 (0.78) | ALDH1A1USP2SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL12656404 | 0.62 | LIMK2 (0.45) | — | |
| SCHEMBL25493808 | 0.61 | L3MBTL1 (0.53) | ALDH1A1USP2SMN1; SMN2L3MBTL1 | |
| SCHEMBL23160508 | 0.61 | ALDH1A1 (0.41) | NPC1ALDH1A1SMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022098700-A1 | INHIBITING AN IMMUNE RESPONSE MEDIATED BY ONE OR MORE OF TLR2, RAGE, CCR5, CXCR4 AND CD4 | CASSAVA SCIENCES, INC. (US) | 2022-05-12 | — | — | WO | disclosed |