Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ITGAV | P06756 | 2/20 | 0.52 |
| ▸ | HTR6 | P50406 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.47 |
| ▸ | ACLY | P53396 | 1/20 | 0.46 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4622372 | 0.82 | ITGAV (0.60) | NPSR1KDM4EITGAVHTR6ALDH1A1 | |
| SCHEMBL4620131 | 0.82 | ITGAV (0.60) | NPSR1KDM4EITGAVHTR6ALDH1A1 | |
| SCHEMBL4618939 | 0.82 | ITGAV (0.60) | NPSR1KDM4EITGAVHTR6ALDH1A1 | |
| SCHEMBL2371550 | 0.79 | L3MBTL1 (0.61) | ITGAVHTR6CA1CA2KAT6A | |
| SCHEMBL29965203 | 0.79 | L3MBTL1 (0.61) | ITGAVHTR6CA1CA2KAT6A | |
| SCHEMBL12962526 | 0.78 | NPSR1 (0.67) | NPSR1KDM4EALDH1A1TSHR | |
| SCHEMBL13049842 | 0.78 | L3MBTL1 (0.69) | NPSR1KDM4EALDH1A1 | |
| SCHEMBL28844042 | 0.78 | HTR6 (0.55) | ITGAVHTR6CA1CA2ALDH1A1 | |
| SCHEMBL29288590 | 0.78 | HTR6 (0.55) | ITGAVHTR6CA1CA2KAT6A | |
| SCHEMBL5501632 | 0.78 | HTR6 (0.55) | ITGAVHTR6CA1CA2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220153734-A1 | Pyrazolopyridine Compounds For IRE1 Inhibition | Optikira, LLC | 2022-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220153734-A1 | Pyrazolopyridine Compounds For IRE1 Inhibition | XBP1, ERN1, ERN2 | NPSR1 4716/4885KDM4E 1043/4885ITGAV 4870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.