SCHEMBL24435974

SCHEMBL24435974

C#Cc1cnc(C#C)nc1

nearest known ligand 0.38

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 2/20 0.38
MAP3K14 Q99558 2/20 0.31
PARP1 P09874 1/20 0.31
KEAP1 Q14145 1/20 0.30
EGLN1 Q9GZT9 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24942540 0.81 KDM4E (0.48)
SCHEMBL1330734 0.79 HDAC8 (0.39) HDAC8PARP1KEAP1EGLN1
SCHEMBL934894 0.74
SCHEMBL17321845 0.74
SCHEMBL1262340 0.74
SCHEMBL23235300 0.74
SCHEMBL24942541 0.74
SCHEMBL24958838 0.74
SCHEMBL20886067 0.74
SCHEMBL5200955 0.74

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250122132-A1 NITRIFICATION INHIBITORS LINCOLN UNIVERSITY (NZ) 2025-04-17 US disclosed
EP-3990417-B1 IMPROVEMENTS IN AND RELATING TO NITRIFICATION INHIBITORS LINCOLN UNIV (NZ) 2024-03-27 EP disclosed
EP-4339261-A2 IMPROVEMENTS IN AND RELATING TO NITRIFICATION INHIBITORS Lincoln University (NZ) 2024-03-20 EP disclosed
US-20230202941-A1 NITRIFICATION INHIBITORS LINCOLN UNIVERSITY (NZ) 2023-06-29 US disclosed
US-20230202941-A1 NITRIFICATION INHIBITORS LINCOLN UNIVERSITY (NZ) 2023-06-29 US disclosed
US-20230202941-A1 NITRIFICATION INHIBITORS LINCOLN UNIVERSITY (NZ) 2023-06-29 US disclosed
US-11578013-B2 Nitrification inhibitors LINCOLN UNIVERSITY (NZ) 2023-02-14 US disclosed
US-11578013-B2 Nitrification inhibitors LINCOLN UNIVERSITY (NZ) 2023-02-14 US disclosed
US-20220153655-A1 NITRIFICATION INHIBITORS LINCOLN UNIVERSITY (NZ) 2022-05-19 US disclosed
US-20220153655-A1 NITRIFICATION INHIBITORS LINCOLN UNIVERSITY (NZ) 2022-05-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230202941-A1 NITRIFICATION INHIBITORS NOS1, NOS2, NOS3 HDAC8 1783/4885MAP3K14 4001/4885PARP1 4525/4885
US-11578013-B2 Nitrification inhibitors NOS1, NOS2, NOS3 HDAC8 1783/4885MAP3K14 4001/4885PARP1 4525/4885
US-20250122132-A1 NITRIFICATION INHIBITORS NOS1, NOS2, NOS3 HDAC8 1783/4885MAP3K14 4001/4885PARP1 4525/4885
US-20220153655-A1 NITRIFICATION INHIBITORS NOS1, NOS2, NOS3 HDAC8 1783/4885MAP3K14 4001/4885PARP1 4525/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.