Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 11/20 | 0.78 |
| ▸ | LMNA | P02545 | 7/20 | 0.77 |
| ▸ | MAPT | P10636 | 7/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.77 |
| ▸ | TP53 | P04637 | 5/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.77 |
| ▸ | USP2 | O75604 | 4/20 | 0.77 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.77 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.77 |
| ▸ | HTR1A | P08908 | 3/20 | 0.77 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.77 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.77 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.77 |
| ▸ | DRD1 | P21728 | 3/20 | 0.77 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.77 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.77 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.77 |
| ▸ | DRD3 | P35462 | 3/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21445210 | 0.88 | FPR2 (1.00) | FPR2LMNAMAPTMAPK1TP53 | |
| Fluphenazine SCHEMBL19221 | 0.87 | LMNA (1.00) | FPR2LMNAMAPTMAPK1TP53 | |
| Fluphenazine SCHEMBL5072860 | 0.87 | LMNA (1.00) | FPR2LMNAMAPTMAPK1TP53 | |
| Fluphenazine SCHEMBL29354183 | 0.87 | LMNA (1.00) | FPR2LMNAMAPTMAPK1TP53 | |
| Fluphenazine SCHEMBL29388890 | 0.87 | LMNA (1.00) | FPR2LMNAMAPTMAPK1TP53 | |
| SCHEMBL561399 | 0.87 | LMNA (0.75) | FPR2LMNAMAPTMAPK1TP53 | |
| SCHEMBL14809956 | 0.87 | TP53 (0.72) | FPR2LMNAMAPTMAPK1TP53 | |
| SCHEMBL14724203 | 0.87 | TP53 (0.72) | FPR2LMNAMAPTMAPK1TP53 | |
| SCHEMBL4273505 | 0.86 | FPR2 (0.75) | FPR2LMNAMAPTMAPK1TP53 | |
| Fluphenazine SCHEMBL7194252 | 0.86 | LMNA (0.98) | FPR2LMNAMAPTMAPK1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240025868-A1 | PHENOTHIAZINE COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND OTHER AGE-RELATED AND NEUROLOGICAL DISEASES | ICAHN SCHOOL MED MOUNT SINAI (US) | 2024-01-25 | — | — | US | disclosed |
| US-20240025868-A1 | PHENOTHIAZINE COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND OTHER AGE-RELATED AND NEUROLOGICAL DISEASES | ICAHN SCHOOL MED MOUNT SINAI (US) | 2024-01-25 | — | — | US | disclosed |
| WO-2022104070-A2 | PHENOTHIAZINE COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND OTHER AGE-RELATED AND NEUROLOGICAL DISEASES | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240025868-A1 | PHENOTHIAZINE COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND OTHER AGE-RELATED AND NEUROLOGICAL DISEASES | ACE2, BACE2, PSEN2 | FPR2 244/4885LMNA 1414/4885MAPT 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.