SCHEMBL24445876

SCHEMBL24445876

O=COc1cc(O)cc(F)c1

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.48
CA1 P00915 1/20 0.48
CA9 Q16790 1/20 0.48
HCAR1 Q9BXC0 1/20 0.41
PTGS1 P23219 2/20 0.35
ERN1 O75460 1/20 0.35
PTGS2 P35354 1/20 0.32
LCK P06239 1/20 0.31
ESR1 P03372 1/20 0.31
ESR2 Q92731 1/20 0.31
NPC1 O15118 1/20 0.31
GAA P10253 1/20 0.31
MAPT P10636 1/20 0.31
RAB9A P51151 1/20 0.31
HSD17B1 P14061 1/20 0.31
HSD17B2 P37059 1/20 0.31
CYP4F2 P78329 1/20 0.30
CYP4A11 Q02928 1/20 0.30
SOD1 P00441 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL524065 0.84 LCK (0.43) CA12CA1CA9PTGS1PTGS2
SCHEMBL2005178 0.84 CES2 (0.35) CA12CA1CA9ERN1CYP4F2
Methane SCHEMBL27792691 0.82 LCK (0.42) CA12CA1CA9PTGS1PTGS2
SCHEMBL3471004 0.77 ALDH5A1 (0.39) PTGS2LCKMAPTRAB9A
SCHEMBL97383 0.75 ALDH1A1 (0.34) ERN1MAPTCYP4F2CYP4A11
Resorcinol SCHEMBL28044421 0.75 CYP3A4 (0.50) CA12CA1CA9LCKESR1
SCHEMBL18623053 0.75 ALDH1A1 (0.31) MAPT
SCHEMBL8804437 0.75 ALDH1A1 (0.48) HCAR1ERN1PTGS2ESR1ESR2
SCHEMBL24445831 0.75 AURKA (0.40) GAAMAPT
SCHEMBL24445655 0.74 ERN1 (0.42) PTGS1ERN1ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4001336-A1 POLYURETHANE, POLYURETHANE PRODUCTION METHOD, CONDUCTIVE PASTE COMPOSITION, CONDUCTIVE WIRE, AND METHOD FOR PRODUCING CONDUCTIVE WIRE Shin-Etsu Chemical Co., Ltd. (JP) 2022-05-25 EP disclosed