SCHEMBL24445994

SCHEMBL24445994

COC(=O)Cc1ccc(-c2cccc(Cl)c2)ccc[nH]c1

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 2/20 0.44
RORC P51449 2/20 0.44
MAOB P27338 2/20 0.42
VEGFA P15692 1/20 0.42
FLT1 P17948 1/20 0.42
EGLN1 Q9GZT9 1/20 0.42
EGLN3 Q9H6Z9 1/20 0.42
ACLY P53396 1/20 0.41
SLC6A3 Q01959 2/20 0.41
MMP2 P08253 1/20 0.40
MMP9 P14780 1/20 0.40
MMP8 P22894 1/20 0.40
MMEL1 Q495T6 2/20 0.40
MME P08473 3/20 0.40
ACE P12821 2/20 0.40
SLC6A2 P23975 1/20 0.40
HCAR2 Q8TDS4 1/20 0.40
NR1H4 Q96RI1 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19068063 0.87 TAAR1 (0.54) TAAR1RORCMAOBVEGFAFLT1
SCHEMBL24612546 0.86 ICMT (0.45) MMEHCAR2NR1H4
SCHEMBL24445987 0.86 HPGD (0.46)
SCHEMBL24612554 0.79 MAOB (0.48) TAAR1MAOBNR1H4
SCHEMBL3357146 0.74 GAA (0.55) NR1H4
SCHEMBL4010965 0.74 SLC7A5 (0.47)
SCHEMBL378633 0.74 SLC7A5 (0.55) MAOB
SCHEMBL4228874 0.73 CYP4F2 (0.50)
SCHEMBL19068062 0.72 MAPT (0.58)
SCHEMBL22624267 0.71 TAAR1 (0.59) TAAR1RORCMAOBMMP2MMP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4026828-A1 AUXIN-INDUCIBLE DEGRON SYSTEM KIT AND USE THEREOF Inter-University Research Institute Corporation Research Organization of Information and Systems (JP) 2022-07-13 EP disclosed
EP-4001414-A1 NONHUMAN ANIMAL AND USE FOR SAME Inter-University Research Institute Corporation Research Organization of Information and Systems (JP) 2022-05-25 EP disclosed