SCHEMBL24612554

SCHEMBL24612554

COCCc1ccc(-c2cccc(Cl)c2)ccc[nH]c1

nearest known ligand 0.48

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.48
TAAR1 Q96RJ0 2/20 0.48
PGR P06401 5/20 0.39
GRM2 Q14416 1/20 0.37
ESR2 Q92731 1/20 0.36
TP53 P04637 1/20 0.36
ALOX5 P09917 1/20 0.36
MCHR1 Q99705 1/20 0.35
NR1H4 Q96RI1 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24445994 0.79 TAAR1 (0.44) MAOBTAAR1NR1H4
SCHEMBL3096336 0.71 TAAR1 (0.57) TAAR1
SCHEMBL2220568 0.70 PDE4B (0.42) MAOBTAAR1TP53
SCHEMBL9269074 0.69 MAOB (0.53) MAOBTAAR1MCHR1
SCHEMBL19523120 0.69 MAOB (0.69) MAOBTAAR1PGRGRM2ESR2
SCHEMBL24445925 0.69 HDAC8 (0.40)
SCHEMBL1127129 0.69 NUDT1 (0.42) MAOBTAAR1TP53
SCHEMBL1623905 0.68 TAAR1 (0.69) MAOBTAAR1PGRGRM2ESR2
SCHEMBL11103639 0.68 KCNH2 (0.48) MAOBTAAR1
SCHEMBL12926311 0.67 MAOB (0.48) MAOBTAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4026828-A1 AUXIN-INDUCIBLE DEGRON SYSTEM KIT AND USE THEREOF Inter-University Research Institute Corporation Research Organization of Information and Systems (JP) 2022-07-13 EP disclosed