Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.81 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 4/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | RAD52 | P43351 | 2/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.36 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.35 |
| ▸ | CDK9 | P50750 | 2/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31371552 | 1.00 | MAPK14 (0.81) | MAPK14AXLALDH1A1SMN1; SMN2CDK2 | |
| SCHEMBL2445182 | 0.95 | MAPK14 (0.73) | MAPK14AXLALDH1A1HTR2AHTR2C | |
| SCHEMBL31371595 | 0.92 | MAPK14 (0.72) | MAPK14AXLALDH1A1HTR2AHTR2C | |
| Arry-797 SCHEMBL29349798 | 0.90 | MAPK14 (1.00) | MAPK14ALDH1A1SMN1; SMN2CDK2CDK1 | |
| Arry-797 SCHEMBL222635 | 0.90 | MAPK14 (1.00) | MAPK14ALDH1A1SMN1; SMN2CDK2CDK1 | |
| Arry-797 SCHEMBL29351662 | 0.90 | MAPK14 (1.00) | MAPK14ALDH1A1SMN1; SMN2CDK2CDK1 | |
| Arry-797 SCHEMBL31046796 | 0.90 | MAPK14 (1.00) | MAPK14ALDH1A1SMN1; SMN2CDK2CDK1 | |
| SCHEMBL31371520 | 0.89 | MAPK14 (0.70) | MAPK14ALDH1A1HTR2CRAD52MCHR2 | |
| SCHEMBL2446702 | 0.87 | MAPK14 (0.62) | MAPK14AXLALDH1A1SMN1; SMN2CDK2 | |
| SCHEMBL2443317 | 0.87 | MAPK14 (0.63) | MAPK14ALDH1A1SMN1; SMN2MCHR2MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10441577-B2 | Medicament for treatment of liver cancer | HELMHOLTZ ZENTRUM FUER INFEKTIONSFORSCHUNG (DE) | 2019-10-15 | — | — | US | disclosed |
| US-20150079154-A1 | MEDICAMENT FOR TREATMENT OF LIVER CANCER | HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH (DE) | 2015-03-19 | — | — | US | disclosed |
| US-8017641-B2 | P38 inhibitors and methods of use thereof | ARRAY BIOPHARMA INC. (US) | 2011-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10441577-B2 | Medicament for treatment of liver cancer | PYGL, PFKL, GLS2 | MAPK14 523/4885AXL 296/4885ALDH1A1 1054/4885 |
| US-20150079154-A1 | MEDICAMENT FOR TREATMENT OF LIVER CANCER | PYGL, PFKL, GLS2 | MAPK14 523/4885AXL 296/4885ALDH1A1 1054/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.