Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.62 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2445182 | 0.88 | MAPK14 (0.73) | MAPK14MEN1KMT2AHIPK4KDM4E | |
| SCHEMBL31371552 | 0.86 | MAPK14 (0.81) | MAPK14HIPK4HTR2AHTR2CPTGER4 | |
| SCHEMBL2443328 | 0.86 | MAPK14 (0.81) | MAPK14HIPK4HTR2AHTR2CPTGER4 | |
| SCHEMBL2443317 | 0.86 | MAPK14 (0.63) | MAPK14MEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL2448328 | 0.84 | MAPK14 (0.61) | MAPK14MCHR2MCHR1 | |
| SCHEMBL2450289 | 0.84 | MAPK14 (0.57) | MAPK14KMT2AKDM4EHSD17B10MCHR1 | |
| SCHEMBL2450576 | 0.83 | MAPK14 (0.59) | MAPK14KDM4ENR3C1PTGER4PTGER2 | |
| SCHEMBL2446126 | 0.82 | MAPK14 (0.56) | MAPK14HIPK4HTR2AHTR2CNR3C1 | |
| SCHEMBL2450377 | 0.81 | MAPK14 (0.55) | MAPK14HTR2AHTR2CHTR2BIRAK4 | |
| SCHEMBL5296566 | 0.80 | MAPK14 (0.54) | MAPK14HIPK4HTR2AHTR2CNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606283-A4 | P38 INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2007-05-23 | — | — | EP | disclosed |
| EP-1606283-A2 | P38 INHIBITORS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004078116-A2 | P38 INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA, INC. (US) | 2004-09-16 | — | — | WO | disclosed |