SCHEMBL2445600

SCHEMBL2445600

CCOC(=O)c1cnc(Cl)cc1N

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.50
NPC1 O15118 5/20 0.49
RAB9A P51151 5/20 0.49
KDM4E B2RXH2 3/20 0.49
ALDH1A1 P00352 6/20 0.49
KMT2A Q03164 2/20 0.49
MEN1 O00255 1/20 0.49
HSD17B10 Q99714 1/20 0.49
SMN1; SMN2 Q16637 4/20 0.48
MAPT P10636 2/20 0.47
TP53 P04637 1/20 0.47
CSNK1D P48730 1/20 0.47
HTT P42858 1/20 0.46
DPP4 P27487 2/20 0.46
HPGD P15428 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
NFKB1 P19838 1/20 0.45
NFKB2 Q00653 1/20 0.45
RELA Q04206 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29374466 1.00 HSP90AA1 (0.50) HSP90AA1NPC1RAB9AKDM4EALDH1A1
SCHEMBL4468614 0.88 ALDH1A1 (0.49) HSP90AA1NPC1RAB9AKDM4EALDH1A1
SCHEMBL31437304 0.88 ALDH1A1 (0.49) HSP90AA1NPC1RAB9AKDM4EALDH1A1
SCHEMBL3516119 0.85 BAZ2B (0.49) HSP90AA1NPC1RAB9AKDM4EALDH1A1
SCHEMBL29574609 0.84 BAZ2B (0.51) HSP90AA1KDM4EALDH1A1KMT2AMEN1
SCHEMBL13982866 0.84 DGAT1 (0.49) HSP90AA1NPC1RAB9AKDM4EALDH1A1
SCHEMBL190973 0.84 BAZ2B (0.51) HSP90AA1KDM4EALDH1A1KMT2AMEN1
SCHEMBL24341947 0.83 KMT2A (0.46) HSP90AA1NPC1RAB9AKDM4EALDH1A1
SCHEMBL29557951 0.83 KMT2A (0.46) HSP90AA1NPC1RAB9AKDM4EALDH1A1
SCHEMBL7855992 0.83 CA12 (0.53) HSP90AA1KDM4EALDH1A1KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 142 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109651241-B Synthesis method of 4-bromo-6-chloronicotinaldehyde 上海毕得医药科技股份有限公司 2021-02-09 CN claimed
US-12630566-B2 KRas G12D inhibitors Mirati Therapeutics, Inc. (US) 2026-05-19 US disclosed
WO-2026101924-A1 KRAS MODULATORS ALTEROME THERAPEUTICS, INC. (US) 2026-05-15 WO disclosed
US-12528828-B2 Substituted pyrido[4,3-d]pyrimidines as KRAS modulators ALTEROME THERAPEUTICS, INC. (US) 2026-01-20 US disclosed
US-20250346610-A1 SUBSTITUTED PYRIDO[4,3-d]PYRIMIDINES AS KRAS MODULATORS ALTEROME THERAPEUTICS INC (US) 2025-11-13 US disclosed
US-12466842-B2 Substituted pyrido [4,3-d]pyrimidines as KRAS modulators ALTEROME THERAPEUTICS, INC. (US) 2025-11-11 US disclosed
US-20250282799-A1 SUBSTITUTED PYRIDO[4,3-d]PYRIMIDINES AS KRAS MODULATORS ALTEROME THERAPEUTICS, INC. 2025-09-11 US disclosed
EP-3919496-B1 POLYCYCLIC COMPOUND INHIBITING MNK1 AND MNK2 NOVOSTAR PHARMACEUTICALS LTD (CN) 2025-09-10 EP disclosed
US-20250179093-A1 KRAS MODULATORS ALTEROME THERAPEUTICS, INC. 2025-06-05 US disclosed
WO-2025064542-A1 KRAS MODULATORS ALTEROME THERAPEUTICS, INC. (US) 2025-03-27 WO disclosed
WO-2013134298-A1 RAF INHIBITOR COMPOUNDS DECIPHERA PHARMACEUTICALS, LLC (US) 2013-09-12 WO disclosed
WO-2011157397-A1 HETEROARYL IMIDAZOLONE DERIVATIVES AS JAK INHIBITORS ALMIRALL, S.A. (ES) 2011-12-22 WO disclosed
EP-2380877-A1 PYRIDINE-3-CARBOXYAMIDE DERIVATIVE Kowa Company, Ltd. (JP) 2011-10-26 EP disclosed
US-20110237590-A1 PYRIDINE-3-CARBOXYAMIDE DERIVATIVE KOWA COMPANY, LTD. (JP) 2011-09-29 US disclosed
US-7160888-B2 [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia WARNER LAMBERT COMPANY LLC (US) 2007-01-09 US disclosed
US-20060287309-A1 [1,8]NAPHTHYRIDIN-2-ONES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA WARNER-LAMBERT COMPANY LLC 2006-12-21 US disclosed
US-20060287310-A1 [1,8]NAPHTHYRIDIN-2-ONES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA WARNER-LAMBERT COMPANY LLC 2006-12-21 US disclosed
EP-1660497-A1 [ 1,8]NAPHTHYRIDIN-2-ONES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA Warner-Lambert Company LLC (US) 2006-05-31 EP disclosed
WO-2005019215-A1 [1,8]NAPHTHYRIDIN-2-ONES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA WARNER-LAMBERT COMPANY LLC (US) 2005-03-03 WO disclosed
US-20050043309-A1 [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia WARNER-LAMBERT COMPANY LLC 2005-02-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250179093-A1 KRAS MODULATORS KRAS, NRAS, HRAS HSP90AA1 1713/4885NPC1 2198/4885RAB9A 96/4885
US-20050043309-A1 [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia DRD1, DRD2, DRD3 HSP90AA1 3614/4885NPC1 1164/4885RAB9A 276/4885
US-20250346610-A1 SUBSTITUTED PYRIDO[4,3-d]PYRIMIDINES AS KRAS MODULATORS KRAS, NRAS, HRAS HSP90AA1 3813/4885NPC1 3624/4885RAB9A 105/4885
US-12466842-B2 Substituted pyrido [4,3-d]pyrimidines as KRAS modulators KRAS, NRAS, HRAS HSP90AA1 3813/4885NPC1 3624/4885RAB9A 105/4885
US-12630566-B2 KRas G12D inhibitors KRAS, NRAS, HRAS HSP90AA1 2786/4885NPC1 2476/4885RAB9A 58/4885
US-20250282799-A1 SUBSTITUTED PYRIDO[4,3-d]PYRIMIDINES AS KRAS MODULATORS KRAS, NRAS, HRAS HSP90AA1 3813/4885NPC1 3624/4885RAB9A 105/4885
US-12528828-B2 Substituted pyrido[4,3-d]pyrimidines as KRAS modulators KRAS, NRAS, HRAS HSP90AA1 3676/4885NPC1 1122/4885RAB9A 88/4885
US-20060287309-A1 [1,8]NAPHTHYRIDIN-2-ONES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA DRD1, DRD2, DRD3 HSP90AA1 3614/4885NPC1 1164/4885RAB9A 276/4885
US-20060287310-A1 [1,8]NAPHTHYRIDIN-2-ONES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA DRD1, DRD2, DRD3 HSP90AA1 3614/4885NPC1 1164/4885RAB9A 276/4885
US-20110237590-A1 PYRIDINE-3-CARBOXYAMIDE DERIVATIVE JAK3, JAK1, UACA HSP90AA1 3422/4885NPC1 4679/4885RAB9A 2317/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.