SCHEMBL2445733

SCHEMBL2445733

CC[C@H](Nc1ccccc1)[Si](OC)(OC)OC

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.42
ALDH1A1 P00352 5/20 0.37
CYP3A4 P08684 3/20 0.37
ALOX15 P16050 3/20 0.37
TSHR P16473 3/20 0.37
HSD17B10 Q99714 3/20 0.37
THRB P10828 2/20 0.37
L3MBTL1 Q9Y468 2/20 0.37
ALOX12 P18054 2/20 0.37
LMNA P02545 1/20 0.37
RECQL P46063 1/20 0.37
ATM Q13315 1/20 0.37
GAA P10253 2/20 0.37
HIF1A Q16665 2/20 0.36
TP53 P04637 1/20 0.36
HSP90AA1 P07900 1/20 0.36
CASP1 P29466 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
MAPK1 P28482 1/20 0.36
MAPT P10636 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL125182 1.00 TDP1 (0.42) TDP1ALDH1A1CYP3A4ALOX15TSHR
SCHEMBL10943391 0.93 TDP1 (0.37) TDP1ALDH1A1CYP3A4ALOX15TSHR
SCHEMBL16147719 0.92 TDP1 (0.36) TDP1ALDH1A1CYP3A4ALOX15TSHR
SCHEMBL19579594 0.91 TDP1 (0.35) TDP1ALDH1A1CYP3A4ALOX15TSHR
SCHEMBL2117717 0.86 TDP1 (0.39) TDP1ALDH1A1CYP3A4ALOX15TSHR
SCHEMBL3450824 0.84 TDP1 (0.41) TDP1ALDH1A1CYP3A4ALOX15TSHR
SCHEMBL138740 0.84 TDP1 (0.41) TDP1ALDH1A1CYP3A4ALOX15TSHR
SCHEMBL9069335 0.82 TDP1 (0.39) TDP1ALDH1A1CYP3A4ALOX15TSHR
SCHEMBL5685206 0.82 ALDH1A1 (0.38) TDP1ALDH1A1CYP3A4ALOX15TSHR
SCHEMBL27944700 0.82 APP (0.33) TSHRGAAMAPK1MAPTNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12372893-B2 Carrier, developer, image forming method, and process cartridge RICOH COMPANY, LTD. (JP) 2025-07-29 US disclosed
EP-4198635-B1 DEVELOPING APPARATUS, DEVELOPER FOR ELECTROPHOTOGRAPHIC IMAGE FORMATION, ELECTROPHOTOGRAPHIC IMAGE FORMING METHOD, AND ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS RICOH CO LTD (JP) 2024-05-22 EP disclosed
US-11934145-B2 Developing apparatus, developer for electrophotographic image formation, electrophotographic image forming method, and electrophotographic image forming apparatus RICOH COMPANY, LTD. (JP) 2024-03-19 US disclosed
US-20230205108-A1 CARRIER, DEVELOPER, IMAGE FORMING METHOD, AND PROCESS CARTRIDGE RICOH COMPANY ,LTD. (JP) 2023-06-29 US disclosed
US-20230195004-A1 DEVELOPING APPARATUS, DEVELOPER FOR ELECTROPHOTOGRAPHIC IMAGE FORMATION, ELECTROPHOTOGRAPHIC IMAGE FORMING METHOD, AND ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2023-06-22 US disclosed
EP-4198635-A1 DEVELOPING APPARATUS, DEVELOPER FOR ELECTROPHOTOGRAPHIC IMAGE FORMATION, ELECTROPHOTOGRAPHIC IMAGE FORMING METHOD, AND ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS Ricoh Company, Ltd. (JP) 2023-06-21 EP disclosed
CN-112782947-A Carrier and developer for electrophotographic image formation, electrophotographic image formation method and apparatus 株式会社理光 2021-05-11 CN disclosed
US-10254674-B2 Carrier for developer of electrostatic latent image, developer, and image forming apparatus RICOH COMPANY, LTD. (JP) 2019-04-09 US disclosed
US-20180113393-A1 CARRIER FOR DEVELOPER OF ELECTROSTATIC LATENT IMAGE, DEVELOPER, AND IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2018-04-26 US disclosed
EP-2347306-B1 CARRIER, DEVELOPER, AND IMAGE FORMING METHOD RICOH CO LTD (JP) 2015-08-26 EP disclosed
US-9086647-B2 Developing device that suppresses hysteresis RICOH COMPANY, LTD. (JP) 2015-07-21 US disclosed
US-20140072349-A1 DEVELOPING DEVICE AND IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2014-03-13 US disclosed
US-8431312-B2 Carrier, developer, and image forming method RICOH COMPANY, LTD. (JP) 2013-04-30 US disclosed
US-20110217649-A1 CARRIER, DEVELOPER, AND IMAGE FORMING METHOD RICOH COMPANY, LTD. (JP) 2011-09-08 US disclosed