Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | PARP11 | Q9NR21 | 2/20 | 0.33 |
| ▸ | F12 | P00748 | 5/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 2/20 | 0.31 |
| ▸ | CASP7 | P55210 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CRHBP | P24387 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22702928 | 0.89 | KDM4E (0.39) | PARP1F12CASP1CASP7KDM4E | |
| SCHEMBL2261586 | 0.79 | PARP10 (0.39) | PARP10PARP1GRM5PARP11HTR2A | |
| SCHEMBL17433704 | 0.79 | PARP10 (0.43) | PARP10PARP1GRM5PARP11HTR2A | |
| SCHEMBL24457967 | 0.77 | PARP10 (0.42) | PARP10PARP1PARP11HTR2AHTR2C | |
| SCHEMBL16593595 | 0.76 | PARP10 (0.37) | PARP10PARP1GRM5PARP11 | |
| SCHEMBL24457975 | 0.76 | MEN1 (0.41) | PARP10PARP1GRM5PARP11HTR2A | |
| SCHEMBL8648955 | 0.76 | PARP10 (0.41) | PARP10PARP1PARP11HTR2AHTR2C | |
| SCHEMBL8651032 | 0.76 | DRD2 (0.46) | PARP10PARP1PARP11CASP1CASP7 | |
| SCHEMBL24457970 | 0.73 | DRD2 (0.40) | PARP10PARP1GRM5PARP11ALDH1A1 | |
| SCHEMBL10300799 | 0.73 | PARP1 (0.35) | PARP10PARP1GRM5HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109001-A1 | GCN2 AND PERK KINASE INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC (US) | 2022-05-27 | — | — | WO | disclosed |