Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 5/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.32 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.31 |
| ▸ | ALB | P02768 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17433704 | 0.76 | PARP10 (0.43) | DRD2GRM5PARP10PARP11PARP1 | |
| SCHEMBL24457975 | 0.73 | MEN1 (0.41) | DRD2PNMTGRM5PARP10PARP11 | |
| SCHEMBL8651032 | 0.73 | DRD2 (0.46) | DRD2PARP10PARP11PARP1ALDH1A1 | |
| SCHEMBL24457969 | 0.73 | PARP10 (0.37) | GRM5PARP10PARP11PARP1ALDH1A1 | |
| SCHEMBL8648955 | 0.73 | PARP10 (0.41) | PNMTPARP10PARP11PARP1ALDH1A1 | |
| SCHEMBL19684587 | 0.71 | PNMT (0.53) | DRD2DRD3PNMT | |
| SCHEMBL24457967 | 0.70 | PARP10 (0.42) | KDM1APARP10PARP11PARP1 | |
| SCHEMBL14279957 | 0.70 | ACHE (0.48) | GRM5PARP1ALDH1A1 | |
| SCHEMBL14330930 | 0.70 | ADRA2A (0.41) | PARP10PARP11PARP1 | |
| SCHEMBL21903872 | 0.70 | KDM1A (0.33) | GRM5KDM1APARP10PARP11PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109001-A1 | GCN2 AND PERK KINASE INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC (US) | 2022-05-27 | — | — | WO | disclosed |