Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | HTR2B | P41595 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | PARP11 | Q9NR21 | 3/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21866002 | 0.81 | PARP10 (0.42) | PARP10PARP1HTR2AHTR2CHTR2B | |
| SCHEMBL21865762 | 0.80 | PARP10 (0.41) | PARP10PARP1HTR2AHTR2CHTR2B | |
| SCHEMBL24457969 | 0.77 | PARP10 (0.37) | PARP10PARP1HTR2AHTR2CMEN1 | |
| SCHEMBL17433704 | 0.76 | PARP10 (0.43) | PARP10PARP1HTR2AHTR2CHTR2B | |
| SCHEMBL8651032 | 0.73 | DRD2 (0.46) | PARP10PARP1HTR2BMEN1CASP1 | |
| SCHEMBL24457975 | 0.73 | MEN1 (0.41) | PARP10PARP1HTR2AHTR2CHTR2B | |
| SCHEMBL8648955 | 0.73 | PARP10 (0.41) | PARP10PARP1HTR2AHTR2CHTR2B | |
| SCHEMBL19684578 | 0.71 | ASIC3 (0.43) | PARP10PARP1HTR2AHTR2CHTR2B | |
| SCHEMBL24457970 | 0.70 | DRD2 (0.40) | PARP10PARP1PARP11KDM1A | |
| SCHEMBL14330930 | 0.70 | ADRA2A (0.41) | PARP10PARP1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109001-A1 | GCN2 AND PERK KINASE INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC (US) | 2022-05-27 | — | — | WO | disclosed |