Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.79 |
| ▸ | GLA | P06280 | 1/20 | 0.79 |
| ▸ | ST6GAL1 | P15907 | 10/20 | 0.61 |
| ▸ | P2RY2 | P41231 | 4/20 | 0.57 |
| ▸ | P2RY4 | P51582 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | MTOR | P42345 | 1/20 | 0.54 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.54 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.54 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL503814 | 0.95 | TSHR (0.81) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Choline SCHEMBL28018234 | 0.93 | TSHR (0.76) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Pyrophosphoric Acid SCHEMBL760216 | 0.93 | TSHR (0.79) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| SCHEMBL11616961 | 0.92 | TSHR (0.78) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Cytarabine 5'-Phosphate SCHEMBL18441379 | 0.91 | TSHR (0.75) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Cystetine Triphosphate SCHEMBL11613107 | 0.90 | TSHR (0.79) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Citicoline SCHEMBL667104 | 0.90 | TSHR (0.84) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Citicoline SCHEMBL30969948 | 0.89 | TSHR (0.82) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Cytarabine 5'-Phosphate SCHEMBL18441374 | 0.89 | TSHR (0.68) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Citicoline SCHEMBL25411862 | 0.88 | TSHR (0.76) | TSHRGLAST6GAL1P2RY2P2RY4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111808890-A | Method for efficiently degrading antibiotics in livestock and poultry breeding waste by using microorganisms | 嘉兴市爵拓科技有限公司 | 2020-10-23 | — | — | CN | claimed |
| CN-115896217-A | Feed supplementing process for improving fermentation level of tulathromycin | 内蒙古中牧生物药业有限公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-112384203-A | Lipid emulsions for parenteral administration | 费森尤斯卡比德国有限公司 | 2021-02-19 | — | — | CN | disclosed |
| CN-111808890-A | Method for efficiently degrading antibiotics in livestock and poultry breeding waste by using microorganisms | 嘉兴市爵拓科技有限公司 | 2020-10-23 | — | — | CN | disclosed |
| CN-111808890-A | Method for efficiently degrading antibiotics in livestock and poultry breeding waste by using microorganisms | 嘉兴市爵拓科技有限公司 | 2020-10-23 | — | — | CN | disclosed |
| EP-1600482-B1 | Liquid composition for metachromatic members, and its use | PILOT INK CO LTD (JP) | 2018-04-04 | — | — | EP | disclosed |
| CN-104592335-A | Method for synthesizing nucleoside diphosphonic acid choline sodium salts | UNIV JIANGXI NORMAL SCI & TECH | 2015-05-06 | — | — | CN | disclosed |
| US-8025961-B2 | Liquid composition for metachromatic members, and metachromatic member set making use of the same | THE PILOT INK CO., LTD. (JP) | 2011-09-27 | — | — | US | disclosed |
| CN-101829137-A | Solid preparation with citicoline sodium and inosine as active ingredients and applications thereof | BEIJING LILESHENG PHARMACEUTICAL TECHNOLOGY CO LTD | 2010-09-15 | — | — | CN | disclosed |
| CN-101829136-A | Oral liquid preparation with citicoline sodium and inosine as active ingredients and application thereof | BEIJING LILESHENG PHARMACEUTICAL TECHNOLOGY CO LTD | 2010-09-15 | — | — | CN | disclosed |
| CN-101829135-A | Injection preparation with citicoline sodium and inosine as active ingredients, and application thereof | BEIJING LILESHENG PHARMACEUTICAL TECHNOLOGY CO LTD | 2010-09-15 | — | — | CN | disclosed |
| US-7632564-B2 | Liquid composition for metachromatic members, and metachromatic member set making use of the same | THE PILOT INK CO., LTD. (JP) | 2009-12-15 | — | — | US | disclosed |
| US-20090071370-A1 | LIQUID COMPOSITION FOR METACHROMATIC MEMBERS, AND METACHROMATIC MEMBER SET MAKING USE OF THE SAME | THE PILOT INK CO., LTD. (JP) | 2009-03-19 | — | — | US | disclosed |
| EP-1600482-A1 | Liquid composition for metachromatic members, and its use | THE PILOT INK CO., LTD. (JP) | 2005-11-30 | — | — | EP | disclosed |
| US-20050260362-A1 | Liquid composition for metachromatic members, and metachromatic member set making use of the same | THE PILOT INK CO., LTD. (JP) | 2005-11-24 | — | — | US | disclosed |
| CN-1562345-A | Drug combination including activator for metabolism of brain and free radical scavenger | YANG XIHONG (CN) | 2005-01-12 | — | — | CN | disclosed |
| CN-1513468-A | Compound medicine of sodium citicoline and disodium cytidine triphosphate | 杨喜鸿 | 2004-07-21 | — | — | CN | disclosed |