Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Citicoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY2 known ✓ | P41231 | 4/20 | 0.60 |
| ▸ | P2RY4 known ✓ | P51582 | 2/20 | 0.60 |
| ▸ | P2RY6 known ✓ | Q15077 | 2/20 | 0.54 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.84 |
| ▸ | GLA | P06280 | 1/20 | 0.84 |
| ▸ | ST6GAL1 | P15907 | 10/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MTOR | P42345 | 1/20 | 0.53 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.53 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.53 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citicoline SCHEMBL30969948 | 0.99 | TSHR (0.82) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| SCHEMBL1794713 | 0.96 | TSHR (0.76) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Citicoline SCHEMBL221081 | 0.93 | TSHR (0.73) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Citicoline SCHEMBL31413926 | 0.93 | TSHR (0.73) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Citicoline SCHEMBL31554836 | 0.93 | TSHR (0.73) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Citicoline SCHEMBL25411862 | 0.93 | TSHR (0.76) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Citicoline SCHEMBL4311534 | 0.93 | TSHR (0.76) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Citicoline SCHEMBL50799 | 0.93 | TSHR (0.73) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Citicoline SCHEMBL19347200 | 0.93 | TSHR (0.72) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Choline SCHEMBL503814 | 0.91 | TSHR (0.81) | TSHRGLAST6GAL1P2RY2P2RY4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 655 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117045613-B | Pharmaceutical composition for treating diabetic peripheral neuropathy and preparation method thereof | 重庆康刻尔制药股份有限公司 | 2026-05-12 | — | — | CN | claimed |
| US-20250302856-A1 | METHODS AND NUTRACEUTICAL COMPOSITIONS FOR THE PROMOTION OF WAKEFULNESS AND ALERTNESS | KAPLAN IP, LLC (US) | 2025-10-02 | — | — | US | claimed |
| CN-119523931-B | Polypyrrole-based stimulus response type bionic drug-loaded nanoparticle and preparation method thereof | 复旦大学 | 2025-06-24 | — | — | CN | claimed |
| WO-2025040605-A1 | OPHTHALMOLOGICAL COMPOSITION CONTAINING AT LEAST ONE NICOTINIC ACETYLCHOLINE RECEPTOR MODULATOR FOR TOPICAL ADMINISTRATION TO THE EYE FOR PREVENTING OR TREATING INFLAMMATION OF THE EYE | URSAPHARM ARZNEIMITTEL GMBH (DE) | 2025-02-27 | — | — | WO | claimed |
| CN-119280149-A | Citicoline sodium injection and preparation method thereof | 海南全星制药有限公司 | 2025-01-10 | — | — | CN | claimed |
| CN-118961947-A | Quantitative detection method of phosphorylcholine in citicoline sodium injection | 锦州奥鸿药业有限责任公司 | 2024-11-15 | — | — | CN | claimed |
| CN-118948756-A | Citicoline sodium injection and preparation method thereof | 浙江诚意药业股份有限公司 | 2024-11-15 | — | — | CN | claimed |
| CN-221867671-U | Novel citicoline sodium purification device | 朱素娟 | 2024-10-22 | — | — | CN | claimed |
| CN-221816090-U | Cytophosphoric choline sodium preparation tank with filtering structure | 宁夏华吉生物有限公司 | 2024-10-11 | — | — | CN | claimed |
| CN-118581179-A | Method for synthesizing citicoline sodium by catalyzing cytidine in one pot by multi-enzyme system | 深圳华酶生物科技有限公司 | 2024-09-03 | — | — | CN | claimed |
| CN-102010454-A | Citicoline sodium compound and new method thereof | JIANRONG HU | 2011-04-13 | — | — | CN | claimed |
| CN-101204396-A | Citicoline sodium dispersible tablets and preparation method thereof | SHANGHAI TAIPINGYANG PHARMACEU (CN) | 2008-06-25 | — | — | CN | claimed |
| CN-101130797-A | Ubelin manufacturing technique | JIAN ZHANG (CN) | 2008-02-27 | — | — | CN | claimed |
| EP-1041992-A4 | HYPERHYDRATED CITICOLINE, PROCESS AND USE | FERRER INT (ES) | 2007-05-09 | — | — | EP | claimed |
| CN-1817344-A | Technology for treating twist disease, hypotension and hypertension | LI JINGXIANG (CN) | 2006-08-16 | — | — | CN | claimed |
| EP-1005349-B1 | USE OF CYTIDINE-CONTAINING AND CYTOSINE-CONTAINING COMPOUNDS AS TREATMENTS FOR STIMULANT EXPOSURE | MCLEAN HOSPITAL CORP (US) | 2005-07-27 | — | — | EP | claimed |
| CN-1395935-A | Citicoline sodium injection for intravenous injection and its preparing process | LI DAPENG (CN) | 2003-02-12 | — | — | CN | claimed |
| EP-1041992-A1 | HYPERHYDRATED CITICOLINE, PROCESS AND USE | INTERNEURON PHARMACEUTICALS INCORPORATED (US) | 2000-10-11 | — | — | EP | claimed |
| US-6057301-A | MOISTURE RESISTANT, IMPROVED STORAGE STABILITY | INTERNEURON PHARMACEUTICALS, INC. (US) | 2000-05-02 | — | — | US | claimed |
| WO-1999033476-A1 | HYPERHYDRATED CITICOLINE, PROCESS AND USE | INTERNEURON PHARMACEUTICALS, INC. (US) | 1999-07-08 | — | — | WO | claimed |