Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.81 |
| ▸ | GLA | P06280 | 1/20 | 0.81 |
| ▸ | ST6GAL1 | P15907 | 10/20 | 0.62 |
| ▸ | P2RY2 | P41231 | 2/20 | 0.58 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | MTOR | P42345 | 1/20 | 0.56 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.56 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.56 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrophosphoric Acid SCHEMBL760216 | 0.98 | TSHR (0.79) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Choline SCHEMBL2446082 | 0.95 | TSHR (0.79) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Choline SCHEMBL28018234 | 0.93 | TSHR (0.76) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Cytarabine 5'-Phosphate SCHEMBL18441379 | 0.93 | TSHR (0.75) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| SCHEMBL29356399 | 0.92 | TSHR (0.81) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| SCHEMBL5407898 | 0.92 | TSHR (0.81) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Citicoline SCHEMBL667104 | 0.91 | TSHR (0.84) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Potassium Ion SCHEMBL10585798 | 0.91 | TSHR (0.80) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Citicoline SCHEMBL30969948 | 0.91 | TSHR (0.82) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Cystetine Triphosphate SCHEMBL9101211 | 0.90 | TSHR (0.81) | TSHRGLAST6GAL1P2RY2P2RY4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 709 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12502397-B2 | Parenteral nutrition formulation and methods of preparation thereof | STELLAR BIOMOLECULAR RESEARCH GMBH (DE) | 2025-12-23 | — | — | US | claimed |
| US-20250367206-A1 | 1-METHYLXANTHINE-BASED BIOACTIVE COMPOSITION AND METHOD OF USE THEREOF | Ingenious Ingredients, LP (US) | 2025-12-04 | — | — | US | claimed |
| US-12419860-B2 | Time release sleep aid system | NIGHTWISE, LLC (US) | 2025-09-23 | — | — | US | claimed |
| US-12390470-B2 | 1-methylxanthine-based bioactive composition and method of use thereof | Ingenious Ingredients, LP (US) | 2025-08-19 | — | — | US | claimed |
| US-20250215036-A1 | METHOD FOR PRODUCING CYTIDINE-5'-DIPHOSPHATE COMPOUND | KYOWA HAKKO BIO CO., LTD. (JP) | 2025-07-03 | — | — | US | claimed |
| WO-2025040605-A1 | OPHTHALMOLOGICAL COMPOSITION CONTAINING AT LEAST ONE NICOTINIC ACETYLCHOLINE RECEPTOR MODULATOR FOR TOPICAL ADMINISTRATION TO THE EYE FOR PREVENTING OR TREATING INFLAMMATION OF THE EYE | URSAPHARM ARZNEIMITTEL GMBH (DE) | 2025-02-27 | — | — | WO | claimed |
| EP-4489731-A2 | INTRA-DOSAGE FORM COATINGS AND APPLICATIONS THEREOF | Balchem Corporation (US) | 2025-01-15 | — | — | EP | claimed |
| US-20240415810-A1 | TIME RELEASE SLEEP AID SYSTEM | NIGHTWISE, LLC | 2024-12-19 | — | — | US | claimed |
| CN-118946346-A | Inner coating for dosage forms and use thereof | 百尔康公司 | 2024-11-12 | — | — | CN | claimed |
| EP-4393934-A1 | METHOD FOR PRODUCING CYTIDINE-5'-DIPHOSPHATE COMPOUND | Kyowa Hakko Bio Co., Ltd. (JP) | 2024-07-03 | — | — | EP | claimed |
| EP-1939210-A1 | METHOD FOR PURIFICATION OF CYTIDINEDIPHOSPHORIC CHOLINE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2008-07-02 | — | — | EP | claimed |
| US-20060189566-A1 | Muscle building agent and preventive or remedy for muscle weakening | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-08-24 | — | — | US | claimed |
| US-20060051461-A1 | Nutrified coffee compositions | JAVALUTION COFFEE COMPANY, INC. | 2006-03-09 | — | — | US | claimed |
| EP-1604671-A1 | MUSCLE-BUILDING AGENT AND PREVENTIVE OR REMEDY FOR MUSCLE WEAKENING | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2005-12-14 | — | — | EP | claimed |
| US-6387667-B1 | USING RECOMBINANT MICROORGANISM CULTURES WHICH PRODUCE SPECIFIC ENZYMES AND OROTIC ACID AND CHOLINE AS STARTING MATERIALS | KYOWA HAKKO KOGYO, CO., LTD. (JP) | 2002-05-14 | — | — | US | claimed |
| US-5725852-A | CYTIDINE DIPHOSPHATE CHOLINE ABSORPTION PROMOTER | TAKEDA CHEMICAL INDUSTRIES, LD. (JP) | 1998-03-10 | — | — | US | claimed |
| EP-0553821-B1 | Process for producing cytidine diphosphate choline | KYOWA HAKKO KOGYO KK (JP) | 1997-03-19 | — | — | EP | claimed |
| EP-0566135-A1 | Transmucosal composition comprising a peptide and a cytidine derivative | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-10-20 | — | — | EP | claimed |
| EP-0553821-A1 | Process for producing cytidine diphosphate choline | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-08-04 | — | — | EP | claimed |
| US-RE28886-E | Method for preparing cytidine diphosphate choline | KYOWA HAKKO KOGYO CO., LTD. (JA) | 1976-06-29 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250215036-A1 | METHOD FOR PRODUCING CYTIDINE-5'-DIPHOSPHATE COMPOUND | NUDT1, ENTPD5, ITPA | TSHR 3903/4885GLA 2581/4885ST6GAL1 2531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.