Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 9/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 3/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24464191 | 0.87 | ROCK2 (0.55) | ROCK2ROCK1LMNAMEN1KMT2A | |
| SCHEMBL20661283 | 0.86 | ROCK2 (0.69) | ROCK2ROCK1SLC2A1SLC2A3 | |
| SCHEMBL24464187 | 0.85 | ROCK2 (0.49) | ROCK2ROCK1LMNAHPGDHTT | |
| SCHEMBL17038104 | 0.84 | ROCK2 (0.70) | ROCK2ROCK1SLC2A1SLC2A3 | |
| SCHEMBL24862352 | 0.84 | ROCK2 (0.55) | ROCK2ROCK1MEN1KMT2AHPGD | |
| SCHEMBL17025851 | 0.82 | ROCK2 (0.75) | ROCK2ROCK1MEN1KMT2ASLC2A1 | |
| SCHEMBL24353608 | 0.82 | ROCK2 (0.72) | ROCK2ROCK1SLC2A1SLC2A3 | |
| SCHEMBL24464197 | 0.77 | ROCK2 (0.68) | ROCK2ROCK1HPGDHTTRAB9A | |
| SCHEMBL24741991 | 0.76 | TUBB4A (0.40) | LMNAMEN1KMT2AHPGDHTT | |
| SCHEMBL24862354 | 0.74 | ROCK2 (0.69) | ROCK2ROCK1SLC2A1SLC2A3CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4116293-A2 | RHO KINASE INHIBITORS | Kadmon Corporation, LLC (US) | 2023-01-11 | — | — | EP | disclosed |
| EP-2903618-B1 | RHO KINASE INHIBITORS | KADMON CORP LLC (US) | 2022-06-01 | — | — | EP | disclosed |