Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 9/20 | 0.36 |
| ▸ | PRNP | P04156 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.31 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.30 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.30 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.30 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8404389 | 0.80 | CCR1 (0.39) | EGFRLMNAHPGDHTTALDH1A1 | |
| SCHEMBL29550394 | 0.77 | TRPV1 (0.33) | EGFRGSK3ACDK9CDK5TAOK1 | |
| SCHEMBL30902155 | 0.77 | EGFR (0.32) | EGFREGLN1GSK3ACDK9CDK5 | |
| SCHEMBL19878479 | 0.77 | NQO2 (0.45) | NQO2EGFRPRNPNPSR1ALDH1A1 | |
| SCHEMBL31716595 | 0.74 | SMN1; SMN2 (0.38) | NQO2PRNPNPSR1LMNAHPGD | |
| SCHEMBL3928379 | 0.73 | CCR1 (0.36) | NQO2EGFRPRNPNPSR1LMNA | |
| SCHEMBL38659591 | 0.73 | SRC (0.34) | EGFR | |
| SCHEMBL31610506 | 0.73 | HPGDS (0.39) | EGFRLMNAHTTALDH1A1L3MBTL1 | |
| SCHEMBL29439776 | 0.73 | EPRS1 (0.35) | ALDH1A1 | |
| SCHEMBL10200872 | 0.73 | EGFR (0.37) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4006035-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER | Neupharma, Inc. (US) | 2022-06-01 | — | — | EP | disclosed |